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KDM6A [nucleoplasm]
Stable Identifier
R-HSA-4754224
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lysine-specific demethylase 6A ecNumber1.14.11.-/ecNumber, KDM6A_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDMs demethylate histones (Homo sapiens)
KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA1 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA2 chromatin is activated (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA2 gene is transcribed (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:PKNOX1 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA3 chromatin is activated (Homo sapiens)
HOXA3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXA3 gene is transcribed (Homo sapiens)
MAFB, HOXB1:PBX1:PKNOX1 at active HOXA3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1 activates HOXA2 expression (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:PKNOX1 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1 activates HOXB2 expression (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB2 chromatin is activated (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB2 gene is transcribed (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB3 chromatin is activated (Homo sapiens)
HOXB3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB3 gene is transcribed (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXB4 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXC4 chromatin is activated (Homo sapiens)
HOXC4 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXC4 gene is transcribed (Homo sapiens)
HOXC4 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
HOXD4 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)
HOXA3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MAFB, HOXB1:PBX1:PKNOX1 at active HOXA3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)
HOXB3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA1 chromatin (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB1 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB4 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15550 KDM6A
Gene Names
KDM6A, UTX
Chain
chain:1-1401
Reference Genes
BioGPS Gene:7403 KDM6A
COSMIC (genes):KDM6A KDM6A
CTD Gene:7403 KDM6A
dbSNP Gene:7403 KDM6A
ENSEMBL:ENSG00000147050 KDM6A
HGNC:12637 KDM6A
KEGG Gene (Homo sapiens):7403 KDM6A
Monarch:7403 KDM6A
NCBI Gene:7403 KDM6A
OMIM:300128 KDM6A
UCSC:O15550 KDM6A
Reference Transcript
RefSeq:NM_021140.3 KDM6A
Other Identifiers
0000610086
11743085_a_at
11749091_a_at
17102861
203990_PM_s_at
203990_s_at
203991_PM_s_at
203991_s_at
203992_PM_s_at
203992_s_at
39703_at
3975469
3975470
3975471
3975472
3975473
3975475
3975487
3975490
3975496
3975499
3975503
3975504
3975505
3975506
3975508
3975509
3975510
3975511
3975513
3975514
3975515
3975516
3975517
3975518
3975519
3975520
3975521
3975522
3975524
3975525
3975526
3975527
3975528
3975529
3975533
3975534
3975539
3975541
3975543
3975544
3975545
3975546
3975547
3975548
3975549
4035037
4035043
4035058
4035072
4035091
7403
8166956
A_14_P116222
A_23_P217304
A_33_P3218955
A_33_P3340718
GE54033
GO:0000978
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006325
GO:0006338
GO:0006464
GO:0007507
GO:0008150
GO:0010468
GO:0016491
GO:0031490
GO:0032452
GO:0032991
GO:0035097
GO:0043167
GO:0043226
GO:0044666
GO:0046872
GO:0048856
GO:0051213
GO:0051276
GO:0051568
GO:0071557
GO:0071558
Hs.13980.0.S1_3p_s_at
ILMN_1654488
PH_hs_0022992
TC0X000212.hg
g10863942_3p_a_at
g2580569_3p_a_at
Participates
as a component of
MLL2,3 complex [nucleoplasm] (Homo sapiens)
as a member of
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
Inferred To
KDM6A [nucleoplasm]
(Bos taurus)
KDM6A [nucleoplasm]
(Canis familiaris)
KDM6A [nucleoplasm]
(Sus scrofa)
utx-1 [nucleoplasm]
(Caenorhabditis elegans)
kdm6a [nucleoplasm]
(Danio rerio)
kdm6a [nucleoplasm]
(Xenopus tropicalis)
Kdm6a [nucleoplasm]
(Mus musculus)
Kdm6a [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_066963.2
ZINC - World Drugs
KDM6A_HUMAN
Guide to Pharmacology - Targets
2684
OpenTargets
ENSG00000147050
ZINC - Biogenic
KDM6A_HUMAN
ZINC target
O15550
PRO
O15550
PDB
3AVS
,
3AVR
,
6FUK
,
6FUL
HPA
ENSG00000147050-KDM6A
GeneCards
O15550
Ensembl
ENSG00000147050
,
ENSP00000367203
,
ENST00000377967
Pharos - Targets
O15550
Orphanet
20781
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.708
6
UniProt:Q6ZW49 PAXIP1
1
PAXIP1 [nucleoplasm]
(R-HSA-5619395)
0.643
8
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.643
6
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.597
5
UniProt:O43474 KLF4
1
KLF4 [nucleoplasm]
(R-HSA-434463)
0.536
2
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.536
2
UniProt:O14686 KMT2D
1
KMT2D [nucleoplasm]
(R-HSA-1183219)
0.527
7
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