Reactome | KDM6A [nucleoplasm]

KDM6A [nucleoplasm]

Stable Identifier

R-HSA-4754224

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lysine-specific demethylase 6A ecNumber1.14.11.-/ecNumber, KDM6A_HUMAN, UTX

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15550 KDM6A

Gene Names

KDM6A, UTX

Chain

chain:1-1401

Reference Genes

BioGPS Gene:7403 KDM6A

COSMIC (genes):KDM6A KDM6A

CTD Gene:7403 KDM6A

dbSNP Gene:7403 KDM6A

ENSEMBL:ENSG00000147050 KDM6A

ENSEMBL_homo_sapiens_GENE:ENSG00000147050.18 KDM6A

HGNC:12637 KDM6A

KEGG Gene (Homo sapiens):7403 KDM6A

Monarch:7403 KDM6A

NCBI Gene:7403 KDM6A

OMIM:300128 KDM6A

UCSC:O15550 KDM6A

Reference Transcript

RefSeq:NM_021140.3 KDM6A

Other Identifiers

11743085_a_at

11749091_a_at

17102861

203990_PM_s_at

203990_s_at

203991_PM_s_at

203991_s_at

203992_PM_s_at

203992_s_at

39703_at

3975469

3975470

3975471

3975472

3975473

3975475

3975487

3975490

3975496

3975499

3975503

3975504

3975505

3975506

3975508

3975509

3975510

3975511

3975513

3975514

3975515

3975516

3975517

3975518

3975519

3975520

3975521

3975522

3975524

3975525

3975526

3975527

3975528

3975529

3975533

3975534

3975539

3975541

3975543

3975544

3975545

3975546

3975547

3975548

3975549

4035037

4035043

4035058

4035072

4035091

7403

8166956

A_14_P116222

A_23_P217304

A_33_P3218955

A_33_P3340718

GE54033

GO:0000978

GO:0003677

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006338

GO:0010468

GO:0016491

GO:0031490

GO:0032452

GO:0035097

GO:0036211

GO:0043226

GO:0044666

GO:0046872

GO:0051213

GO:0071558

GO:0140096

Hs.13980.0.S1_3p_s_at

ILMN_1654488

PH_hs_0022992

TC0X000212.hg

g10863942_3p_a_at

g2580569_3p_a_at

Participates

as an input of

as a component of

as a member of

KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)

Inferred To

CYC8 [nucleoplasm] (Saccharomyces cerevisiae)

KDM6A [nucleoplasm] (Bos taurus)

KDM6A [nucleoplasm] (Canis familiaris)

KDM6A [nucleoplasm] (Gallus gallus)

KDM6A [nucleoplasm] (Sus scrofa)

Utx [nucleoplasm] (Drosophila melanogaster)

utx-1 [nucleoplasm] (Caenorhabditis elegans)

trfA [nucleoplasm] (Dictyostelium discoideum)

kdm6a [nucleoplasm] (Xenopus tropicalis)

ssn6 [nucleoplasm] (Schizosaccharomyces pombe)

Kdm6a [nucleoplasm] (Mus musculus)

Kdm6a [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_066963.2

Guide to Pharmacology - Targets

2684

OpenTargets

ENSG00000147050

IntEnz

1.14.11.68

GeneCards

O15550

HPA

ENSG00000147050-KDM6A

Ensembl

ENSP00000367203, ENST00000377967, ENSG00000147050

ZINC target

O15550

PRO

O15550

Pharos - Targets

O15550

Orphanet

20781

PDB

6FUL, 3AVS, 3AVR, 6FUK

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.773	7
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.725	8
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.725	6
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.725	4
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.69	6
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.643	8
UniProt:O15499 GSC2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O43474 KLF4	1	KLF4 [nucleoplasm] (R-HSA-434463)	0.536	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.536	2
UniProt:O14686 KMT2D	1	KMT2D [nucleoplasm] (R-HSA-1183219)	0.527	7
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.527	2

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