Reactome | ash2l [nucleoplasm]

ash2l [nucleoplasm]

Stable Identifier

R-XTR-1629834

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

ASH2L, F7B5C3

Locations in the PathwayBrowser

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Gene expression (Transcription) (Xenopus tropicalis)

- Epigenetic regulation of gene expression (Xenopus tropicalis)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Xenopus tropicalis)
    - Formation of WDR5-containing histone-modifying complexes (Xenopus tropicalis)
      - AKAP8L binds MLL1 complex (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex:AKAP8L [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
      - Formation of the MLL1 complex (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
      - Formation of the RBBP5:ASH2L heterodimer (Xenopus tropicalis)
        
        RBBP5:ASH2L [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
      - Formation of the SET1B complex (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional regulation by RUNX1 (Xenopus tropicalis)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Xenopus tropicalis)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
        
        Core MLL complex [nucleoplasm] (Xenopus tropicalis)
        
        MLL1 complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)
        
        SET1B complex [nucleoplasm] (Xenopus tropicalis)
        
        WRAD complex [nucleoplasm] (Xenopus tropicalis)
        
        ash2l [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F7B5C3

Gene Names

ash2l

Reference Genes

BioGPS Gene:100492052 ash2l

ENSEMBL:ENSXETG00000009007

KEGG:xtr:100492052 ash2l

Monarch:100492052 ash2l

NCBI Gene:100492052 ash2l

UCSC:F7B5C3 ash2l

Reference Transcript

RefSeq:XM_002932722.3 ash2l

Other Identifiers

100492052

GO:0003824

GO:0005634

GO:0005654

GO:0008168

GO:0016740

GO:0032259

GO:0043226

GO:0048188

Participates

as an input of

Formation of the RBBP5:ASH2L heterodimer (Xenopus tropicalis)

as a component of

Inferred From

ASH2L [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSXETT00000019725, ENSXETP00000019725, ENSXETG00000009007

Xenbase

XB-GENE-923264

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