Reactome | NGF-stimulated transcription

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NGF-stimulated transcription Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
created	[InstanceEdit:9031627] Rothfels, Karen, 2017-11-30
dbId	9031628
displayName	NGF-stimulated transcription
doi	10.3180/R-HSA-9031628.1
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-198725] Nuclear Events (kinase and transcription factor activation) - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9031610] p-S133 CREB1, MEF2D and SRF bind the ARC gene - Homo sapiens [Reaction:R-HSA-9031575] AP-1 binds ARC gene - Homo sapiens [Reaction:R-HSA-9031616] EGR binds ARC gene - Homo sapiens [BlackBoxEvent:R-HSA-9031624] ARC gene expression - Homo sapiens [Reaction:R-HSA-9619838] ARC binds DNM2 and SH3GL3 - Homo sapiens [Reaction:R-HSA-9612076] p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters - Homo sapiens [BlackBoxEvent:R-HSA-9612073] NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression - Homo sapiens [Reaction:R-HSA-9612501] SGK phosphorylates CREB1 - Homo sapiens [Reaction:R-HSA-111916] Dimerization of p-S133-CREB1 - Homo sapiens [Reaction:R-HSA-9612509] SGK phosphorylates SRF - Homo sapiens [Reaction:R-HSA-9612514] p-S133 CREB and p-S103 SRF bind the EGR1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9612516] EGR1 gene expression - Homo sapiens [Reaction:R-HSA-9613207] EGR1 binds to the EGR1 promoter - Homo sapiens [Reaction:R-HSA-9613202] EGR1 and NAB co-repressors bind EGR1 gene - Homo sapiens [Reaction:R-HSA-9616105] EGR1 binds CDK5R1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9616110] EGR1-dependent CDK5R1 gene expression - Homo sapiens [Reaction:R-HSA-9616367] NAB2 binds EGR1 to repress CDK5R1 gene expression - Homo sapiens [Reaction:R-HSA-9616368] MyrG-CDK5R1,2 bind CDK5 - Homo sapiens [Reaction:R-HSA-9612483] EGR1,2,3 bind the NAB2 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9612493] EGR-dependent NAB2 gene expression - Homo sapiens [Reaction:R-HSA-9613210] EGR1, EGR2 bind the RRAD promoter - Homo sapiens [BlackBoxEvent:R-HSA-9613219] RRAD gene expression - Homo sapiens [Reaction:R-HSA-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Homo sapiens [Reaction:R-HSA-9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions - Homo sapiens [BlackBoxEvent:R-HSA-9612534] Expression of ID2 and ID4 is repressed by EGR2:NAB - Homo sapiens [Reaction:R-HSA-9613451] p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes - Homo sapiens [BlackBoxEvent:R-HSA-9613460] ID1 and ID3 gene expression - Homo sapiens [Reaction:R-HSA-9621054] REST binds the VGF promoter - Homo sapiens [Reaction:R-HSA-9620663] EGR1 binds the VGF gene - Homo sapiens [Reaction:R-HSA-9620717] p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter - Homo sapiens [BlackBoxEvent:R-HSA-9620723] VGF gene expression - Homo sapiens [Reaction:R-HSA-9621032] EGR1 binds the TPH1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9621048] TPH1 gene expression - Homo sapiens [Reaction:R-HSA-9621035] EGR1 binds the TF gene - Homo sapiens [BlackBoxEvent:R-HSA-9621042] TF gene expression - Homo sapiens [Reaction:R-HSA-9621385] EGR1 binds TRIB1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9621386] TRIB1 gene expression - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:9012471] Strong association between c-myb and oestrogen-receptor expression in human breast cancer [LiteratureReference:9621783] Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system [LiteratureReference:9610094] Transcription factors and effectors that regulate neuronal morphology
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	NGF-stimulated transcription
orthologousEvent	[Pathway:R-DRE-9031628] NGF-stimulated transcription - Danio rerio [Pathway:R-SCE-9031628] NGF-stimulated transcription - Saccharomyces cerevisiae [Pathway:R-SPO-9031628] NGF-stimulated transcription - Schizosaccharomyces pombe [Pathway:R-DDI-9031628] NGF-stimulated transcription - Dictyostelium discoideum [Pathway:R-CEL-9031628] NGF-stimulated transcription - Caenorhabditis elegans [Pathway:R-MMU-9031628] NGF-stimulated transcription - Mus musculus [Pathway:R-RNO-9031628] NGF-stimulated transcription - Rattus norvegicus [Pathway:R-CFA-9031628] NGF-stimulated transcription - Canis familiaris [Pathway:R-BTA-9031628] NGF-stimulated transcription - Bos taurus [Pathway:R-SSC-9031628] NGF-stimulated transcription - Sus scrofa [Pathway:R-GGA-9031628] NGF-stimulated transcription - Gallus gallus [Pathway:R-DME-9031628] NGF-stimulated transcription - Drosophila melanogaster
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9031628
summation	[Summation:9621780] NGF stimulation induces expression of a wide array of transc...
updateTrackers	[UpdateTracker:9864135] Update Tracker - [Pathway:9031628] NGF-stimulated transcription - v88:[updateContainedRLE] [UpdateTracker:9776914] Update Tracker - [Pathway:9031628] NGF-stimulated transcription - v74:[addHasEvent] [UpdateTracker:9846809] Update Tracker - [Pathway:9031628] NGF-stimulated transcription - v84:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-198725] Nuclear Events (kinase and transcription factor activation)
(updatedInstance)	[UpdateTracker:9864135] Update Tracker - [Pathway:9031628] NGF-stimulated transcription - v88:[updateContainedRLE] [UpdateTracker:9776914] Update Tracker - [Pathway:9031628] NGF-stimulated transcription - v74:[addHasEvent] [UpdateTracker:9846809] Update Tracker - [Pathway:9031628] NGF-stimulated transcription - v84:[updateContainedRLE]

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