Reactome | NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression

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NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613214] Rothfels, Karen, 2018-07-11
dbId	9613213
displayName	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3702078] CHD4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9612177] NAB2 [nucleoplasm] [Complex:R-HSA-9613167] RRAD gene:EGR2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9612329] NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli [LiteratureReference:9612479] Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain [LiteratureReference:9613097] NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex [LiteratureReference:9613066] Active gene repression by the Egr2.NAB complex during peripheral nerve myelination [LiteratureReference:9613095] Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation [LiteratureReference:9613126] Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart [LiteratureReference:9613122] Rad GTPase deficiency leads to cardiac hypertrophy [LiteratureReference:9613147] The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway [LiteratureReference:9613105] Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases [LiteratureReference:9613144] Rho kinase regulates schwann cell myelination and formation of associated axonal domains
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression
orthologousEvent	[Reaction:R-DRE-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Danio rerio [Reaction:R-CEL-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Caenorhabditis elegans [Reaction:R-DME-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Drosophila melanogaster [Reaction:R-SSC-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Sus scrofa [Reaction:R-BTA-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Bos taurus [Reaction:R-CFA-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Canis familiaris [Reaction:R-RNO-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Rattus norvegicus [Reaction:R-MMU-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Mus musculus
output	[Complex:R-HSA-9613187] RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9613210] EGR1, EGR2 bind the RRAD promoter - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9613213
summation	[Summation:9613212] NAB2 is recruited to EGR2 to the RRAD promoter through inter...

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[Pathway:R-HSA-9031628] NGF-stimulated transcription

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