Reactome | p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters

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p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9612075] Rothfels, Karen, 2018-06-25
dbId	9612076
displayName	p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
input	[DefinedSet:R-HSA-9612056] EGR1, EGR2, EGR4 genes [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3009350] p-4S,T336-ELK1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5666000] SRF [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9612353] v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements [LiteratureReference:9612347] Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements [LiteratureReference:9612033] Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate [LiteratureReference:9612306] A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes [LiteratureReference:9612324] Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1 [LiteratureReference:9612426] Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death [LiteratureReference:9610764] Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells [LiteratureReference:9612312] ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription [LiteratureReference:9612035] The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience [LiteratureReference:9611984] Activation and function of immediate-early genes in the nervous system [LiteratureReference:9612009] Early growth response 1--a transcription factor in the crossfire of signal transduction cascades
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters
output	[Complex:R-HSA-9612059] p-4S, T336 ELK1:SRF:EGR1,EGR2 genes [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9612076
summation	[Summation:9612532] Expression of Early Growth Response (EGR) genes is dependent...

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[Pathway:R-HSA-9031628] NGF-stimulated transcription

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