Reactome | EGR1 gene expression

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EGR1 gene expression Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9612503] Rothfels, Karen, 2018-06-28
dbId	9612516
displayName	EGR1 gene expression
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
followingEvent	[Reaction:R-HSA-9613210] EGR1, EGR2 bind the RRAD promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9034181] EGR1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9612009] Early growth response 1--a transcription factor in the crossfire of signal transduction cascades [LiteratureReference:9612019] Gene regulation in the immediate-early response process [LiteratureReference:9611984] Activation and function of immediate-early genes in the nervous system [LiteratureReference:9612028] Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins [LiteratureReference:9612035] The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience [LiteratureReference:9611999] Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4 [LiteratureReference:9612033] Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate [LiteratureReference:9612004] ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 [LiteratureReference:9612017] Full promoter sequence of human early growth response factor-1 (Egr-1): demonstration of a fifth functional serum response element [LiteratureReference:9612343] Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB [LiteratureReference:9612339] Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation [LiteratureReference:9612047] The human transcriptional repressor protein NAB1: expression and biological activity [LiteratureReference:9612329] NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR1 gene expression
output	[EntityWithAccessionedSequence:R-HSA-1031703] EGR1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9612514] p-S133 CREB and p-S103 SRF bind the EGR1 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9612506] Positive gene expression regulation by 'EGR1 gene:p-S133 CREB:p-S103 SRF [nucleoplasm]' [PositiveGeneExpressionRegulation:9613196] Positive gene expression regulation by 'EGR1 gene:EGR1 [nucleoplasm]' [NegativeGeneExpressionRegulation:9613191] Negative gene expression regulation by 'EGR1 gene:EGR1:NAB1,NAB2 [nucleoplasm]'
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9612516
summation	[Summation:9612502] Early Growth Response 1 (EGR) is an immediate early gene tha...

Referrals

(hasEvent)	[Pathway:R-HSA-9031628] NGF-stimulated transcription
(precedingEvent)	[Reaction:R-HSA-9613210] EGR1, EGR2 bind the RRAD promoter

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