Reactome | MyrG-CDK5R1,2 bind CDK5

Schema > Reaction > Entries

MyrG-CDK5R1,2 bind CDK5 Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9616372] Rothfels, Karen, 2018-08-10
dbId	9616368
displayName	MyrG-CDK5R1,2 bind CDK5
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
inferredFrom	[Reaction:R-RNO-9616370] MyrG-Cdk5r1(2-307) binds Cdk5 - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-180064] CDK5 [cytosol] [CandidateSet:R-HSA-9616816] MyrG-CDK5R1,2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8862817] p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 [LiteratureReference:9616058] A brain-specific activator of cyclin-dependent kinase 5 [LiteratureReference:9612004] ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 [LiteratureReference:9616039] The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation [LiteratureReference:9616047] Role of cyclins in neuronal differentiation of immortalized hippocampal cells [LiteratureReference:9616079] Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth [LiteratureReference:8862819] An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MyrG-CDK5R1,2 bind CDK5
output	[Complex:R-HSA-9616817] CDK5:MyrG-CDK5R1,2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9616110] EGR1-dependent CDK5R1 gene expression - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9616368
summation	[Summation:9616371] CDK5R1 is a neuron-specific regulatory subunit of CDK5 that ...

Referrals

(hasEvent)	[Pathway:R-HSA-9031628] NGF-stimulated transcription
(inferredTo)	[Reaction:R-RNO-9616370] MyrG-Cdk5r1(2-307) binds Cdk5