Reactome | EGR1 and NAB co-repressors bind EGR1 gene

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EGR1 and NAB co-repressors bind EGR1 gene Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613203] Rothfels, Karen, 2018-07-11
dbId	9613202
displayName	EGR1 and NAB co-repressors bind EGR1 gene
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1031703] EGR1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9034181] EGR1 gene [nucleoplasm] 2 × [DefinedSet:R-HSA-9612546] NAB1,2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9613156] Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor [LiteratureReference:9612022] Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription [LiteratureReference:9612329] NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli [LiteratureReference:9612470] Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop [LiteratureReference:9612464] EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin [LiteratureReference:9613097] NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex [LiteratureReference:9612481] Novel mutants of NAB corepressors enhance activation by Egr transactivators [LiteratureReference:9612461] A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene [LiteratureReference:9613103] Nab proteins are essential for peripheral nervous system myelination
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR1 and NAB co-repressors bind EGR1 gene
output	[Complex:R-HSA-9613178] EGR1 gene:EGR1:NAB1,NAB2 [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9613202
summation	[Summation:9613201] EGR1 expression is repressed by the recruitment of NAB prote...

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[Pathway:R-HSA-9031628] NGF-stimulated transcription