Reactome | p-S133 CREB and p-S103 SRF bind the EGR1 promoter

Schema > Reaction > Entries

p-S133 CREB and p-S103 SRF bind the EGR1 promoter Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9612503] Rothfels, Karen, 2018-06-28
dbId	9612514
displayName	p-S133 CREB and p-S103 SRF bind the EGR1 promoter
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9612516] EGR1 gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9034181] EGR1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9612518] p-S103 SRF [nucleoplasm] [Complex:R-HSA-111911] p-S133-CREB1 homodimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9612353] v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements [LiteratureReference:9612347] Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements [LiteratureReference:9612306] A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes [LiteratureReference:9612324] Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1 [LiteratureReference:9612426] Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death [LiteratureReference:9612339] Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation [LiteratureReference:9612343] Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB [LiteratureReference:9612312] ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription [LiteratureReference:199893] Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene [LiteratureReference:8984841] Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-S133 CREB and p-S103 SRF bind the EGR1 promoter
output	[Complex:R-HSA-9612517] EGR1 gene:p-S133 CREB:p-S103 SRF [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9612501] SGK phosphorylates CREB1 - Homo sapiens [Reaction:R-HSA-9612509] SGK phosphorylates SRF - Homo sapiens [Reaction:R-HSA-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Homo sapiens [Reaction:R-HSA-199917] MAPKAPK2 phosphorylates CREB at Serine 133 - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9612514
summation	[Summation:9612513] Expression of EGR1 depends in part on the binding of phospho...

Referrals

(hasEvent)	[Pathway:R-HSA-9031628] NGF-stimulated transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-9612516] EGR1 gene expression

Cite Us!