Reactome | VGF gene expression

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VGF gene expression Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	omitted
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:7660] nucleoplasm
created	[InstanceEdit:9620715] Rothfels, Karen, 2018-09-25
dbId	9620723
displayName	VGF gene expression
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9620667] VGF gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9620673] Nucleotide sequence and regulatory studies of VGF, a nervous system-specific mRNA that is rapidly and relatively selectively induced by nerve growth factor [LiteratureReference:9620664] Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells [LiteratureReference:9620685] NGF induces the expression of the VGF gene through a cAMP response element [LiteratureReference:9620699] Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and tyrosine hydroxylase [LiteratureReference:9620722] VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance [LiteratureReference:9620656] A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway [LiteratureReference:9620708] Tissue-specific processing of the neuroendocrine protein VGF [LiteratureReference:9620654] A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway [LiteratureReference:9620688] Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF [LiteratureReference:9620720] VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers [LiteratureReference:9620674] Molecular cloning and characterization of the human VGF promoter region [LiteratureReference:9620665] Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene [LiteratureReference:9620669] Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene [LiteratureReference:9620658] Activation of codependent transcription factors is required for transcriptional induction of the vgf gene by nerve growth factor and Ras [LiteratureReference:9031578] Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation [LiteratureReference:9610764] Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells [LiteratureReference:9620687] NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VGF gene expression
output	[EntityWithAccessionedSequence:R-HSA-8956769] VGF [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-9620717] p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter - Homo sapiens [Reaction:R-HSA-9620663] EGR1 binds the VGF gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9620692] Positive gene expression regulation by 'VGF gene:p-CREB:p-ATFs:ASCL1:TCF12:EP300 [nucleoplasm]' [PositiveGeneExpressionRegulation:9620691] Positive gene expression regulation by 'VGF gene:EGR1 [nucleoplasm]' [NegativeGeneExpressionRegulation:9621058] Negative gene expression regulation by 'VGF gene:REST [nucleoplasm]'
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9620723
summation	[Summation:9620719] VGF is a neurosecretory protein that is expressed in neurona...

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[Pathway:R-HSA-9031628] NGF-stimulated transcription

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