Reactome | SGK phosphorylates SRF

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SGK phosphorylates SRF Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
catalystActivity	[CatalystActivity:9612499] protein serine/threonine kinase activity of p-T256,S422-SGK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9612503] Rothfels, Karen, 2018-06-28
dbId	9612509
displayName	SGK phosphorylates SRF
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
followingEvent	[Reaction:R-HSA-9612514] p-S133 CREB and p-S103 SRF bind the EGR1 promoter - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5666000] SRF [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9612339] Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation [LiteratureReference:9612343] Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB [LiteratureReference:9612009] Early growth response 1--a transcription factor in the crossfire of signal transduction cascades
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SGK phosphorylates SRF
orthologousEvent	[Reaction:R-DRE-9612509] SGK phosphorylates SRF - Danio rerio [Reaction:R-SCE-9612509] SGK phosphorylates SRF - Saccharomyces cerevisiae [Reaction:R-SPO-9612509] SGK phosphorylates SRF - Schizosaccharomyces pombe [Reaction:R-DDI-9612509] SGK phosphorylates SRF - Dictyostelium discoideum [Reaction:R-CEL-9612509] SGK phosphorylates SRF - Caenorhabditis elegans [Reaction:R-SSC-9612509] SGK phosphorylates SRF - Sus scrofa [Reaction:R-CFA-9612509] SGK phosphorylates SRF - Canis familiaris [Reaction:R-RNO-9612509] SGK phosphorylates SRF - Rattus norvegicus [Reaction:R-MMU-9612509] SGK phosphorylates SRF - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9612518] p-S103 SRF [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9612509
summation	[Summation:9612507] Serum/glucticocorticoid kinase (SGK) phosphorylates SRF at s...

Referrals

(hasEvent)	[Pathway:R-HSA-9031628] NGF-stimulated transcription
(precedingEvent)	[Reaction:R-HSA-9612514] p-S133 CREB and p-S103 SRF bind the EGR1 promoter