Reactome | NGF-stimulated transcription

NGF-stimulated transcription

Stable Identifier

R-HSA-9031628

DOI

10.3180/R-HSA-9031628.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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NGF stimulation induces expression of a wide array of transcriptional targets. In rat PC12 cells, a common model for NGF signaling, stimulation with NGF causes cells to exit the cell cycle and undergo a differentiation program leading to neurite outgrowth. This program is driven by the expression of immediate early genes (IEGs), which frequently encode transcription factors regulating the activity of NGF-specific delayed response genes (reviewed in Sheng and Greenberg, 1990; Flavell and Grennberg, 2008; Santiago and Bashaw, 2014).

Literature References

PubMed ID	Title	Journal	Year
18558867	Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system Flavell, SW, Greenberg, ME	Annu. Rev. Neurosci.	2008
25468936	Transcription factors and effectors that regulate neuronal morphology Santiago, C, Bashaw, GJ	Development	2014
2181374	Strong association between c-myb and oestrogen-receptor expression in human breast cancer Guérin, M, Sheng, ZM, Andrieu, N, Riou, G	Oncogene	1990