Reactome | Expression of ID2 and ID4 is repressed by EGR2:NAB

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Expression of ID2 and ID4 is repressed by EGR2:NAB Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9612535] Rothfels, Karen, 2018-06-28
dbId	9612534
displayName	Expression of ID2 and ID4 is repressed by EGR2:NAB
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
eventOf	[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
input	[DefinedSet:R-HSA-9612537] ID2, ID4 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9613399] Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms [LiteratureReference:9613409] Id family of helix-loop-helix proteins in cancer [LiteratureReference:9613471] Id proteins: small molecules, mighty regulators [LiteratureReference:9613066] Active gene repression by the Egr2.NAB complex during peripheral nerve myelination [LiteratureReference:9613097] NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex [LiteratureReference:9613444] The nucleosome remodeling and deacetylase chromatin remodeling (NuRD) complex is required for peripheral nerve myelination
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of ID2 and ID4 is repressed by EGR2:NAB
output	[DefinedSet:R-HSA-9612533] ID2, ID4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions - Homo sapiens
regulatedBy	[NegativeRegulation:9613473] Negative regulation by 'ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm]'
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9612534
summation	[Summation:9613467] ID1-4 (Inhibitor of DNA-binding) are members of the helix-lo...

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(hasEvent)

[Pathway:R-HSA-9031628] NGF-stimulated transcription

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