Reactome | Regulation of RUNX2 expression and activity

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Regulation of RUNX2 expression and activity Show undefined attributes

authored	[InstanceEdit:8939907] Orlic-Milacic, Marija, 2016-09-21
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8939907] Orlic-Milacic, Marija, 2016-09-21
dbId	8939902
displayName	Regulation of RUNX2 expression and activity
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9863075] Orlic-Milacic, Marija, 2024-02-26
eventOf	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2 - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8939904] Activated ESR1 binds the RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-8939929] ESRRA:PPARG1CA binds the RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-8939938] ESRRA:PPARG1CB binds the RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-8940032] TWIST1 binds the RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-9009085] DEXA:NR3C1 complex binds RUNX2 gene proximal promoter - Homo sapiens [Reaction:R-HSA-9016526] RUNX2-P2 binds RUNX2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 - Homo sapiens [Reaction:R-HSA-8985293] NKX3-2 binds RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-9008345] RUNX2-P1 binds RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-9007707] DLX5,(DLX6) binds RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-9007759] MSX2 binds RUNX2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007686] RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) - Homo sapiens [Reaction:R-HSA-9008015] RUNX2 binds STAT1 - Homo sapiens [BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-9008036] RUNX2 binds to HIVEP3 and WWP1 - Homo sapiens [Reaction:R-HSA-9008076] WWP1 polyubiquitinates RUNX2 - Homo sapiens [BlackBoxEvent:R-HSA-9008110] Proteasome degrades polyubiquitinated RUNX2 - Homo sapiens [Reaction:R-HSA-9008476] RUNX2 binds GSK3B - Homo sapiens [Reaction:R-HSA-9008480] GSK3B phosphorylates RUNX2 - Homo sapiens [Reaction:R-HSA-9009309] RUNX2 binds STUB1 - Homo sapiens [Reaction:R-HSA-9009308] STUB1 polyubiquitinates RUNX2 - Homo sapiens [Reaction:R-HSA-9009451] RUNX2 binds SMURF1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9009452] SMURF1 gene expression is stimulated by RUNX2 - Homo sapiens [Reaction:R-HSA-9009401] RUNX2 binds SMURF1 - Homo sapiens [Reaction:R-HSA-9009403] SMURF1 polyubiquitinates RUNX2 - Homo sapiens [BlackBoxEvent:R-HSA-9009362] Proteasome degrades PolyUb-RUNX2 - Homo sapiens [Reaction:R-HSA-8939688] SCF(SKP2) complex binds RUNX2 - Homo sapiens [Reaction:R-HSA-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Homo sapiens [BlackBoxEvent:R-HSA-8939801] 26S proteasome degrades PolyUb-RUNX2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:8939913] Estrogen Receptor ? (ER?) and Estrogen Related Receptor ? (ERR?) are both transcriptional regulators of the Runx2-I isoform [LiteratureReference:8940051] Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST [LiteratureReference:8940505] Advances in Runx2 regulation and its isoforms [LiteratureReference:9009092] Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis [LiteratureReference:8985294] Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation [LiteratureReference:8985456] The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen [LiteratureReference:9008350] Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene [LiteratureReference:9007714] Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter [LiteratureReference:9007782] The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development [LiteratureReference:9008010] Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation [LiteratureReference:9009314] CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation [LiteratureReference:9009409] A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells [LiteratureReference:9009406] E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation [LiteratureReference:9008028] Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3 [LiteratureReference:8939697] Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2 [LiteratureReference:9007856] A twist code determines the onset of osteoblast differentiation [LiteratureReference:8985271] SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation [LiteratureReference:8865398] Cbfbeta interacts with Runx2 and has a critical role in bone development [LiteratureReference:8865395] Mutations in the RUNX2 gene in patients with cleidocranial dysplasia [LiteratureReference:8865422] Core-binding factor beta interacts with Runx2 and is required for skeletal development [LiteratureReference:9016476] A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Regulation of RUNX2 expression and activity
orthologousEvent	[Pathway:R-CFA-8939902] Regulation of RUNX2 expression and activity - Canis familiaris [Pathway:R-CEL-8939902] Regulation of RUNX2 expression and activity - Caenorhabditis elegans [Pathway:R-DME-8939902] Regulation of RUNX2 expression and activity - Drosophila melanogaster [Pathway:R-GGA-8939902] Regulation of RUNX2 expression and activity - Gallus gallus [Pathway:R-XTR-8939902] Regulation of RUNX2 expression and activity - Xenopus tropicalis [Pathway:R-DRE-8939902] Regulation of RUNX2 expression and activity - Danio rerio [Pathway:R-SSC-8939902] Regulation of RUNX2 expression and activity - Sus scrofa [Pathway:R-BTA-8939902] Regulation of RUNX2 expression and activity - Bos taurus [Pathway:R-MMU-8939902] Regulation of RUNX2 expression and activity - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8939902
summation	[Summation:8940506] Several transcription factors have been implicated in regula...
updateTrackers	[UpdateTracker:9778006] Update Tracker - [Pathway:8939902] Regulation of RUNX2 expression and activity - v68:[updateContainedRLE] [UpdateTracker:9864178] Update Tracker - [Pathway:8939902] Regulation of RUNX2 expression and activity - v88:[modifyText, removeHasEvent, removeLiteratureReference, updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2
(updatedInstance)	[UpdateTracker:9778006] Update Tracker - [Pathway:8939902] Regulation of RUNX2 expression and activity - v68:[updateContainedRLE] [UpdateTracker:9864178] Update Tracker - [Pathway:8939902] Regulation of RUNX2 expression and activity - v88:[modifyText, removeHasEvent, removeLiteratureReference, updateContainedRLE]

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