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Schema
>
BlackBoxEvent
>
Entries
RUNX2 translocates to the nucleus
Show undefined attributes
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authored
[InstanceEdit:9007998] Orlic-Milacic, Marija, 2017-06-06
category
omitted
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9007998] Orlic-Milacic, Marija, 2017-06-06
dbId
9007999
displayName
RUNX2 translocates to the nucleus
edited
[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf
[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent
[Reaction:R-HSA-9007860] RUNX2 binds TWIST1,(TWIST2) - Homo sapiens
[Reaction:R-HSA-8985343] RUNX2 binds SOX9 - Homo sapiens
[Reaction:R-HSA-9008476] RUNX2 binds GSK3B - Homo sapiens
[Reaction:R-HSA-8939688] SCF(SKP2) complex binds RUNX2 - Homo sapiens
[Reaction:R-HSA-8938356] RMB14 binds RUNX2 - Homo sapiens
[Reaction:R-HSA-9008326] RUNX2 binds HDAC4 - Homo sapiens
[Reaction:R-HSA-8985275] RUNX2 binds to SATB2 - Homo sapiens
[Reaction:R-HSA-8877902] Activated AR binds RUNX2 - Homo sapiens
[Reaction:R-HSA-8984994] RUNX2 binds MAF - Homo sapiens
[Reaction:R-HSA-8985460] RUNX2 binds RB1 - Homo sapiens
[Reaction:R-HSA-9008137] RUNX2 binds ZNF521 and HDAC3 - Homo sapiens
[Reaction:R-HSA-9008389] RUNX2 binds HDAC6 - Homo sapiens
[Reaction:R-HSA-8865425] RUNX2 binds CBFB - Homo sapiens
[Reaction:R-HSA-9007816] RUNX2 binds HAND2 - Homo sapiens
[Reaction:R-HSA-2064932] WWTR1 (TAZ) binds RUNX2 - Homo sapiens
[Reaction:R-HSA-9008345] RUNX2-P1 binds RUNX2 gene promoter - Homo sapiens
[Reaction:R-HSA-8986294] RUNX2 binds GLI2 - Homo sapiens
[Reaction:R-HSA-9008215] RUNX2 binds GLI3R - Homo sapiens
[Reaction:R-HSA-9008177] RUNX2 binds HEY1,HEY2,HES1 - Homo sapiens
inferredFrom
[BlackBoxEvent:R-MMU-9008009] Runx2 translocates to the nucleus - Mus musculus
input
[CandidateSet:R-HSA-9007986] RUNX2 [cytosol]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:9008010] Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
RUNX2 translocates to the nucleus
output
[CandidateSet:R-HSA-9007751] RUNX2 [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-9007686] RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) - Homo sapiens
[BlackBoxEvent:R-HSA-8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-9008011] Negative regulation by 'RUNX2:STAT1 [cytosol]'
regulationReference
[RegulationReference:9642860] Negative regulation by 'RUNX2:STAT1 [cytosol]' Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
releaseDate
2017-09-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9007999
summation
[Summation:9008013] Based on studies in mice, binding of RUNX2 to cytosolic STAT...
Referrals
(precedingEvent)
[Reaction:R-HSA-9007860] RUNX2 binds TWIST1,(TWIST2)
[Reaction:R-HSA-8985343] RUNX2 binds SOX9
[Reaction:R-HSA-9008476] RUNX2 binds GSK3B
[Reaction:R-HSA-8939688] SCF(SKP2) complex binds RUNX2
[Reaction:R-HSA-8938356] RMB14 binds RUNX2
[Reaction:R-HSA-9008326] RUNX2 binds HDAC4
[Reaction:R-HSA-8986294] RUNX2 binds GLI2
[Reaction:R-HSA-9008215] RUNX2 binds GLI3R
[Reaction:R-HSA-9008177] RUNX2 binds HEY1,HEY2,HES1
[Reaction:R-HSA-8985275] RUNX2 binds to SATB2
[Reaction:R-HSA-8877902] Activated AR binds RUNX2
[Reaction:R-HSA-8984994] RUNX2 binds MAF
[Reaction:R-HSA-8985460] RUNX2 binds RB1
[Reaction:R-HSA-9008137] RUNX2 binds ZNF521 and HDAC3
[Reaction:R-HSA-9008389] RUNX2 binds HDAC6
[Reaction:R-HSA-8865425] RUNX2 binds CBFB
[Reaction:R-HSA-9007816] RUNX2 binds HAND2
[Reaction:R-HSA-2064932] WWTR1 (TAZ) binds RUNX2
[Reaction:R-HSA-9008345] RUNX2-P1 binds RUNX2 gene promoter
(hasEvent)
[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(inferredTo)
[BlackBoxEvent:R-MMU-9008009] Runx2 translocates to the nucleus
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