Reactome | SCF(SKP2) polyubiquitinates RUNX2

Schema > Reaction > Entries

SCF(SKP2) polyubiquitinates RUNX2 Show undefined attributes

authored	[InstanceEdit:8939907] Orlic-Milacic, Marija, 2016-09-21
catalystActivity	[CatalystActivity:8939717] ubiquitin protein ligase activity of RUNX2:SCF(SKP2) [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643203] ubiquitin protein ligase activity of RUNX2:SCF(SKP2) [nucleoplasm] Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8939709] Orlic-Milacic, Marija, 2016-09-21
dbId	8939706
displayName	SCF(SKP2) polyubiquitinates RUNX2
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8939801] 26S proteasome degrades PolyUb-RUNX2 - Homo sapiens
input	[Complex:R-HSA-8939702] RUNX2:SCF(SKP2) [nucleoplasm] 3 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8939697] Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2 [LiteratureReference:9015268] Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	SCF(SKP2) polyubiquitinates RUNX2
orthologousEvent	[Reaction:R-CEL-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Caenorhabditis elegans [Reaction:R-DME-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Drosophila melanogaster [Reaction:R-GGA-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Gallus gallus [Reaction:R-XTR-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Xenopus tropicalis [Reaction:R-DRE-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Danio rerio [Reaction:R-SSC-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Sus scrofa [Reaction:R-BTA-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Bos taurus [Reaction:R-CFA-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Canis familiaris [Reaction:R-MMU-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Mus musculus
output	[CandidateSet:R-HSA-9008122] PolyUb-RUNX2 [nucleoplasm] [Complex:R-HSA-8939693] SCF (SKP2) complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8939688] SCF(SKP2) complex binds RUNX2 - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8939706
summation	[Summation:8939715] The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates ...

Referrals

(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)	[BlackBoxEvent:R-HSA-8939801] 26S proteasome degrades PolyUb-RUNX2