Reactome | Activated ESR1 binds the RUNX2 gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:8939907] Orlic-Milacic, Marija, 2016-09-21
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8939907] Orlic-Milacic, Marija, 2016-09-21
dbId	8939904
displayName	Activated ESR1 binds the RUNX2 gene promoter
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 - Homo sapiens
input	[Complex:R-HSA-1254381] ESR1 dimer:ESTG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8939903] RUNX2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8939913] Estrogen Receptor ? (ER?) and Estrogen Related Receptor ? (ERR?) are both transcriptional regulators of the Runx2-I isoform
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated ESR1 binds the RUNX2 gene promoter
output	[Complex:R-HSA-8939910] ESR1:estrogen:RUNX2 gene [nucleoplasm]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8939904
summation	[Summation:8939908] Activated estrogen receptor alpha (ESR1) binds estrogen resp...

(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)	[BlackBoxEvent:R-HSA-8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1

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