Reactome | WWP1 polyubiquitinates RUNX2

Schema > Reaction > Entries

authored	[InstanceEdit:9008075] Orlic-Milacic, Marija, 2017-06-07
catalystActivity	[CatalystActivity:9008105] ubiquitin protein ligase activity of RUNX2:HIVEP3:WWP1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9008075] Orlic-Milacic, Marija, 2017-06-07
dbId	9008076
displayName	WWP1 polyubiquitinates RUNX2
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9008110] Proteasome degrades polyubiquitinated RUNX2 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9008077] Wwp1 polyubiquitinates Runx2 - Mus musculus
input	[Complex:R-HSA-9008033] RUNX2:HIVEP3:WWP1 [cytosol] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WWP1 polyubiquitinates RUNX2
output	[Complex:R-HSA-9008103] PolyUb-RUNX2:HIVEP3:WWP1 [cytosol]
precedingEvent	[Reaction:R-HSA-9008036] RUNX2 binds to HIVEP3 and WWP1 - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9008076
summation	[Summation:9008078] Studies in mice have shown that once HIVEP3 (SHN3, Schnurri-...

(precedingEvent)	[BlackBoxEvent:R-HSA-9008110] Proteasome degrades polyubiquitinated RUNX2
(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(inferredTo)	[Reaction:R-MMU-9008077] Wwp1 polyubiquitinates Runx2

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