Reactome | RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1

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RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 Show undefined attributes

authored	[InstanceEdit:8939830] Orlic-Milacic, Marija, 2016-09-21
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8939907] Orlic-Milacic, Marija, 2016-09-21
dbId	8939900
displayName	RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent	[Reaction:R-HSA-9009309] RUNX2 binds STUB1 - Homo sapiens [Reaction:R-HSA-9008015] RUNX2 binds STAT1 - Homo sapiens [Reaction:R-HSA-9008036] RUNX2 binds to HIVEP3 and WWP1 - Homo sapiens [BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9009102] Runx2 gene expression from proximal (P2) promoter is stimulated by Runx2-P2 and inhibited by DEXA:Nr3c1 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8939903] RUNX2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8939913] Estrogen Receptor ? (ER?) and Estrogen Related Receptor ? (ERR?) are both transcriptional regulators of the Runx2-I isoform [LiteratureReference:8940051] Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST [LiteratureReference:9009092] Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis [LiteratureReference:9009150] Glucocorticoids antagonize RUNX2 during osteoblast differentiation in cultures of ST2 pluripotent mesenchymal cells [LiteratureReference:9016476] A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1
output	[EntityWithAccessionedSequence:R-HSA-9007987] RUNX2-P2 [cytosol]
precedingEvent	[Reaction:R-HSA-8939904] Activated ESR1 binds the RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-8939929] ESRRA:PPARG1CA binds the RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-8939938] ESRRA:PPARG1CB binds the RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-8940032] TWIST1 binds the RUNX2 gene promoter - Homo sapiens [Reaction:R-HSA-9009085] DEXA:NR3C1 complex binds RUNX2 gene proximal promoter - Homo sapiens [Reaction:R-HSA-9016526] RUNX2-P2 binds RUNX2 gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-8939947] Positive gene expression regulation by 'ESR1:estrogen:RUNX2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8939948] Positive gene expression regulation by 'ESRRA:PPARG1CA:RUNX2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8939949] Negative gene expression regulation by 'ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8940060] Positive gene expression regulation by 'TWIST1:RUNX2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-9009100] Negative gene expression regulation by 'Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9016529] Positive gene expression regulation by 'RUNX2-P2:CBFB:RUNX2 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642075] Positive gene expression regulation by 'ESRRA:PPARG1CA:RUNX2 gene [nucleoplasm]' Estrogen Receptor ? (ER?) and Estrogen Related Receptor ? (ERR?) are both transcriptional regulators of the Runx2-I isoform [RegulationReference:9642206] Negative gene expression regulation by 'Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm]' Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis [RegulationReference:9642322] Positive gene expression regulation by 'ESR1:estrogen:RUNX2 gene [nucleoplasm]' Estrogen Receptor ? (ER?) and Estrogen Related Receptor ? (ERR?) are both transcriptional regulators of the Runx2-I isoform [RegulationReference:9642655] Positive gene expression regulation by 'RUNX2-P2:CBFB:RUNX2 gene [nucleoplasm]' A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development [RegulationReference:9642856] Positive gene expression regulation by 'TWIST1:RUNX2 gene [nucleoplasm]' Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST [RegulationReference:9643014] Negative gene expression regulation by 'ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm]' Estrogen Receptor ? (ER?) and Estrogen Related Receptor ? (ERR?) are both transcriptional regulators of the Runx2-I isoform
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8939900
summation	[Summation:8939921] Activated estrogen receptor alpha (ESR1) directly stimulates...

Referrals

(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)	[Reaction:R-HSA-9009309] RUNX2 binds STUB1 [Reaction:R-HSA-9008015] RUNX2 binds STAT1 [Reaction:R-HSA-9008036] RUNX2 binds to HIVEP3 and WWP1 [BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus
(inferredTo)	[BlackBoxEvent:R-MMU-9009102] Runx2 gene expression from proximal (P2) promoter is stimulated by Runx2-P2 and inhibited by DEXA:Nr3c1

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