Reactome | RUNX2 binds SMURF1

Schema > Reaction > Entries

RUNX2 binds SMURF1 Show undefined attributes

authored	[InstanceEdit:9009404] Orlic-Milacic, Marija, 2017-06-16
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9009404] Orlic-Milacic, Marija, 2017-06-16
dbId	9009401
displayName	RUNX2 binds SMURF1
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent	[Reaction:R-HSA-9009403] SMURF1 polyubiquitinates RUNX2 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9009434] Runx2 binds Smurf1 - Mus musculus
input	[CandidateSet:R-HSA-9007986] RUNX2 [cytosol] [EntityWithAccessionedSequence:R-HSA-975972] SMURF1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9009406] E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation [LiteratureReference:9009409] A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds SMURF1
output	[Complex:R-HSA-9009416] RUNX2:SMURF1 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9009452] SMURF1 gene expression is stimulated by RUNX2 - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9009401
summation	[Summation:9009428] SMURF1, an E3 ubiquitin ligase, binds to RUNX2 (Zhao et al. ...

Referrals

(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)	[Reaction:R-HSA-9009403] SMURF1 polyubiquitinates RUNX2
(inferredTo)	[Reaction:R-MMU-9009434] Runx2 binds Smurf1