Reactome | RUNX2 binds STAT1

Schema > Reaction > Entries

authored	[InstanceEdit:9007998] Orlic-Milacic, Marija, 2017-06-06
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9007998] Orlic-Milacic, Marija, 2017-06-06
dbId	9008015
displayName	RUNX2 binds STAT1
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
inferredFrom	[Reaction:R-MMU-9008004] Runx2 binds Stat1 - Mus musculus
input	[CandidateSet:R-HSA-9007986] RUNX2 [cytosol] [EntityWithAccessionedSequence:R-HSA-629622] STAT1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds STAT1
output	[Complex:R-HSA-9008005] RUNX2:STAT1 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9007686] RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) - Homo sapiens [BlackBoxEvent:R-HSA-8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9008015
summation	[Summation:9008007] Based on studies in mice, RUNX2 forms a complex with non-act...

(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(inferredTo)	[Reaction:R-MMU-9008004] Runx2 binds Stat1