Reactome | Regulation of RUNX2 expression and activity

Schema > Pathway > Entries

Regulation of RUNX2 expression and activity Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10426526
displayName	Regulation of RUNX2 expression and activity
eventOf	[Pathway:R-SSC-8878166] Transcriptional regulation by RUNX2 - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-9009309] RUNX2 binds STUB1 - Sus scrofa [Reaction:R-SSC-9009308] STUB1 polyubiquitinates RUNX2 - Sus scrofa [Reaction:R-SSC-8939688] SCF(SKP2) complex binds RUNX2 - Sus scrofa [Reaction:R-SSC-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Sus scrofa [BlackBoxEvent:R-SSC-8939801] 26S proteasome degrades PolyUb-RUNX2 - Sus scrofa
inferredFrom	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
isInDisease	false
isInferred	true
name	Regulation of RUNX2 expression and activity
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-8939902
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8878166] Transcriptional regulation by RUNX2
(inferredTo)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity

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