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Entries
SCF(SKP2) complex binds RUNX2
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authored
[InstanceEdit:8939907] Orlic-Milacic, Marija, 2016-09-21
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:8939694] Orlic-Milacic, Marija, 2016-09-21
dbId
8939688
displayName
SCF(SKP2) complex binds RUNX2
edited
[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf
[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent
[Reaction:R-HSA-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Homo sapiens
input
[CandidateSet:R-HSA-9007751] RUNX2 [nucleoplasm]
[Complex:R-HSA-8939693] SCF (SKP2) complex [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8939697] Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2
[LiteratureReference:9015268] Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
SCF(SKP2) complex binds RUNX2
orthologousEvent
[Reaction:R-CFA-8939688] SCF(SKP2) complex binds RUNX2 - Canis familiaris
[Reaction:R-CEL-8939688] SCF(SKP2) complex binds RUNX2 - Caenorhabditis elegans
[Reaction:R-DME-8939688] SCF(SKP2) complex binds RUNX2 - Drosophila melanogaster
[Reaction:R-GGA-8939688] SCF(SKP2) complex binds RUNX2 - Gallus gallus
[Reaction:R-DRE-8939688] SCF(SKP2) complex binds RUNX2 - Danio rerio
[Reaction:R-SSC-8939688] SCF(SKP2) complex binds RUNX2 - Sus scrofa
[Reaction:R-BTA-8939688] SCF(SKP2) complex binds RUNX2 - Bos taurus
[Reaction:R-MMU-8939688] SCF(SKP2) complex binds RUNX2 - Mus musculus
output
[Complex:R-HSA-8939702] RUNX2:SCF(SKP2) [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens
releaseDate
2017-09-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8939688
summation
[Summation:8939703] The E3 ubiquitin ligase complex SCF binds RUNX2 through dire...
Referrals
(hasEvent)
[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)
[Reaction:R-HSA-8939706] SCF(SKP2) polyubiquitinates RUNX2
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