Reactome | RUNX2-P1 binds RUNX2 gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:9008332] Orlic-Milacic, Marija, 2017-06-08
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9008354] Orlic-Milacic, Marija, 2017-06-08
dbId	9008345
displayName	RUNX2-P1 binds RUNX2 gene promoter
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9007686] RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) - Homo sapiens
inferredFrom	[Reaction:R-MMU-9008370] Runx2-P1 binds to Runx2 gene promoter - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8939903] RUNX2 gene [nucleoplasm] [Complex:R-HSA-9016495] RUNX2-P1:CBFB [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9008350] Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2-P1 binds RUNX2 gene promoter
output	[Complex:R-HSA-9008361] RUNX2-P1:CBFB:RUNX2 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9008345
summation	[Summation:9008366] Based on studies in mice, RUNX2-P1 (RUNX2 variant expressed ...

(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)	[BlackBoxEvent:R-HSA-9007686] RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6)
(inferredTo)	[Reaction:R-MMU-9008370] Runx2-P1 binds to Runx2 gene promoter

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