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Schema
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Reaction
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Entries
RUNX2 binds STUB1
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authored
[InstanceEdit:9009310] Orlic-Milacic, Marija, 2017-06-16
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9009310] Orlic-Milacic, Marija, 2017-06-16
dbId
9009309
displayName
RUNX2 binds STUB1
edited
[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf
[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent
[Reaction:R-HSA-9009308] STUB1 polyubiquitinates RUNX2 - Homo sapiens
input
[CandidateSet:R-HSA-9007986] RUNX2 [cytosol]
[EntityWithAccessionedSequence:R-HSA-975970] STUB1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9009314] CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
RUNX2 binds STUB1
orthologousEvent
[Reaction:R-CFA-9009309] RUNX2 binds STUB1 - Canis familiaris
[Reaction:R-CEL-9009309] RUNX2 binds STUB1 - Caenorhabditis elegans
[Reaction:R-DME-9009309] RUNX2 binds STUB1 - Drosophila melanogaster
[Reaction:R-GGA-9009309] RUNX2 binds STUB1 - Gallus gallus
[Reaction:R-XTR-9009309] RUNX2 binds STUB1 - Xenopus tropicalis
[Reaction:R-SSC-9009309] RUNX2 binds STUB1 - Sus scrofa
[Reaction:R-BTA-9009309] RUNX2 binds STUB1 - Bos taurus
[Reaction:R-MMU-9009309] RUNX2 binds STUB1 - Mus musculus
output
[Complex:R-HSA-9009311] RUNX2:STUB1 [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-9007686] RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) - Homo sapiens
[BlackBoxEvent:R-HSA-8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 - Homo sapiens
releaseDate
2017-09-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9009309
summation
[Summation:9009315] RUNX2 binds to STUB1 (CHIP), an E3 ubiquitin ligase (Li et a...
Referrals
(hasEvent)
[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)
[Reaction:R-HSA-9009308] STUB1 polyubiquitinates RUNX2
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