Reactome | Proteasome degrades polyubiquitinated RUNX2

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9008111] Orlic-Milacic, Marija, 2017-06-07
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9008111] Orlic-Milacic, Marija, 2017-06-07
dbId	9008110
displayName	Proteasome degrades polyubiquitinated RUNX2
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9008115] Proteasome degrades polyubiquitinated Runx2 - Mus musculus
input	[Complex:R-HSA-9008103] PolyUb-RUNX2:HIVEP3:WWP1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9008028] Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Proteasome degrades polyubiquitinated RUNX2
output	[EntityWithAccessionedSequence:R-HSA-9008029] HIVEP3 [cytosol] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol] [EntityWithAccessionedSequence:R-HSA-976037] WWP1 [cytosol]
precedingEvent	[Reaction:R-HSA-9008076] WWP1 polyubiquitinates RUNX2 - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9008110
summation	[Summation:9008120] Based on studies in mice, proteasome degrades RUNX2 polyubiq...

(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(inferredTo)	[BlackBoxEvent:R-MMU-9008115] Proteasome degrades polyubiquitinated Runx2

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