Reactome | Regulation of RUNX2 expression and activity

Schema > Pathway > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650352
displayName	Regulation of RUNX2 expression and activity
eventOf	[Pathway:R-DRE-8878166] Transcriptional regulation by RUNX2 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-8939688] SCF(SKP2) complex binds RUNX2 - Danio rerio [Reaction:R-DRE-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Danio rerio [BlackBoxEvent:R-DRE-8939801] 26S proteasome degrades PolyUb-RUNX2 - Danio rerio
inferredFrom	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of RUNX2 expression and activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-8939902
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-8878166] Transcriptional regulation by RUNX2
(inferredTo)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity

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