Reactome | DEXA:NR3C1 complex binds RUNX2 gene proximal promoter

Schema > Reaction > Entries

DEXA:NR3C1 complex binds RUNX2 gene proximal promoter Show undefined attributes

authored	[InstanceEdit:9009088] Orlic-Milacic, Marija, 2017-06-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9009088] Orlic-Milacic, Marija, 2017-06-15
dbId	9009085
displayName	DEXA:NR3C1 complex binds RUNX2 gene proximal promoter
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9009091] Nr3c1:DEXA binds Runx2 proximal promoter - Mus musculus
input	[Complex:R-HSA-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8939903] RUNX2 gene [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9009092] Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DEXA:NR3C1 complex binds RUNX2 gene proximal promoter
output	[Complex:R-HSA-9009086] Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9009085
summation	[Summation:9009090] Based on studies in mice, glucocorticoid receptor (NR3C1) ac...

Referrals

(hasEvent)	[Pathway:R-HSA-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)	[BlackBoxEvent:R-HSA-8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1
(inferredTo)	[Reaction:R-MMU-9009091] Nr3c1:DEXA binds Runx2 proximal promoter

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