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Entries
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
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authored
[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:3371552] Shamovsky, V, 2013-05-13
dbId
3371497
displayName
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
doi
10.3180/R-HSA-3371497.1
edited
[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
eventOf
[Pathway:R-HSA-2262752] Cellular responses to stress - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:528568] cellular response to steroid hormone stimulus
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-3371590] HSP70 binds to HSP40:nascent protein - Homo sapiens
[Reaction:R-HSA-3371422] ATP hydrolysis by HSP70 - Homo sapiens
[Reaction:R-HSA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Homo sapiens
[Reaction:R-HSA-5618107] ATP binding to HSP90 triggers conformation change - Homo sapiens
[Reaction:R-HSA-5618105] FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein - Homo sapiens
[Reaction:R-HSA-5618085] FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein - Homo sapiens
[Reaction:R-HSA-5618110] p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein - Homo sapiens
[Reaction:R-HSA-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Homo sapiens
[Reaction:R-HSA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Homo sapiens
[Reaction:R-HSA-9705925] Androgens binds AR (in the HSP90 chaperone complex) - Homo sapiens
[Reaction:R-HSA-9705926] AR binds AR agonists - Homo sapiens
[Reaction:R-HSA-9706837] AR binds AR antagonists - Homo sapiens
[Reaction:R-HSA-9725885] P4 bind PGR (in the HSP90 chaperone complex) - Homo sapiens
[Reaction:R-HSA-9726580] PGR binds PGR agonists - Homo sapiens
[Reaction:R-HSA-9726621] PGR binds PGR antagonists - Homo sapiens
[Reaction:R-HSA-9690534] NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) - Homo sapiens
[Reaction:R-HSA-9678925] NR3C1 binds NR3C1 agonists - Homo sapiens
[Reaction:R-HSA-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Homo sapiens
[Reaction:R-HSA-9725855] NR3C2 binds NR3C2 antagonists - Homo sapiens
[Reaction:R-HSA-9726509] NR3C2 binds fludrocortisone - Homo sapiens
[BlackBoxEvent:R-HSA-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-5618093] ATP hydrolysis by HSP90 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8936892] Hsp90: structure and function
[LiteratureReference:8936890] Structure, function and regulation of the hsp90 machinery
[LiteratureReference:8948280] Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
HSP90 chaperone cycle for SHRs
orthologousEvent
[Pathway:R-MMU-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Mus musculus
[Pathway:R-RNO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Rattus norvegicus
[Pathway:R-CFA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Canis familiaris
[Pathway:R-BTA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Bos taurus
[Pathway:R-SSC-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Sus scrofa
[Pathway:R-DRE-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Danio rerio
[Pathway:R-XTR-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Xenopus tropicalis
[Pathway:R-GGA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Gallus gallus
[Pathway:R-DME-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Drosophila melanogaster
[Pathway:R-CEL-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Caenorhabditis elegans
[Pathway:R-DDI-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Dictyostelium discoideum
[Pathway:R-SPO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Schizosaccharomyces pombe
[Pathway:R-SCE-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Saccharomyces cerevisiae
[Pathway:R-PFA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Plasmodium falciparum
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16
[InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-3371497
summation
[Summation:8936896] Steroid hormone receptors (SHR) are transcription factors th...
Referrals
(hasEvent)
[Pathway:R-HSA-2262752] Cellular responses to stress
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