Reactome | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Show undefined attributes

authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3371552] Shamovsky, V, 2013-05-13
dbId	3371497
displayName	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
doi	10.3180/R-HSA-3371497.1
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
eventOf	[Pathway:R-HSA-2262752] Cellular responses to stress - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:528568] cellular response to steroid hormone stimulus
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-3371590] HSP70 binds to HSP40:nascent protein - Homo sapiens [Reaction:R-HSA-3371422] ATP hydrolysis by HSP70 - Homo sapiens [Reaction:R-HSA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Homo sapiens [Reaction:R-HSA-5618107] ATP binding to HSP90 triggers conformation change - Homo sapiens [Reaction:R-HSA-5618105] FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein - Homo sapiens [Reaction:R-HSA-5618085] FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein - Homo sapiens [Reaction:R-HSA-5618110] p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein - Homo sapiens [Reaction:R-HSA-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Homo sapiens [Reaction:R-HSA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Homo sapiens [Reaction:R-HSA-9705925] Androgens binds AR (in the HSP90 chaperone complex) - Homo sapiens [Reaction:R-HSA-9705926] AR binds AR agonists - Homo sapiens [Reaction:R-HSA-9706837] AR binds AR antagonists - Homo sapiens [Reaction:R-HSA-9725885] P4 bind PGR (in the HSP90 chaperone complex) - Homo sapiens [Reaction:R-HSA-9726580] PGR binds PGR agonists - Homo sapiens [Reaction:R-HSA-9726621] PGR binds PGR antagonists - Homo sapiens [Reaction:R-HSA-9690534] NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) - Homo sapiens [Reaction:R-HSA-9678925] NR3C1 binds NR3C1 agonists - Homo sapiens [Reaction:R-HSA-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Homo sapiens [Reaction:R-HSA-9725855] NR3C2 binds NR3C2 antagonists - Homo sapiens [Reaction:R-HSA-9726509] NR3C2 binds fludrocortisone - Homo sapiens [BlackBoxEvent:R-HSA-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-5618093] ATP hydrolysis by HSP90 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:8936892] Hsp90: structure and function [LiteratureReference:8936890] Structure, function and regulation of the hsp90 machinery [LiteratureReference:8948280] Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSP90 chaperone cycle for SHRs
orthologousEvent	[Pathway:R-MMU-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Mus musculus [Pathway:R-RNO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Rattus norvegicus [Pathway:R-CFA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Canis familiaris [Pathway:R-BTA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Bos taurus [Pathway:R-SSC-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Sus scrofa [Pathway:R-DRE-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Danio rerio [Pathway:R-XTR-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Xenopus tropicalis [Pathway:R-GGA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Gallus gallus [Pathway:R-DME-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Drosophila melanogaster [Pathway:R-CEL-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Caenorhabditis elegans [Pathway:R-DDI-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Dictyostelium discoideum [Pathway:R-SPO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Schizosaccharomyces pombe [Pathway:R-SCE-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Saccharomyces cerevisiae [Pathway:R-PFA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Plasmodium falciparum
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16 [InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3371497
summation	[Summation:8936896] Steroid hormone receptors (SHR) are transcription factors th...
updateTrackers	[UpdateTracker:9774675] Update Tracker - [Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - v81:[addHasEvent] [UpdateTracker:9776779] Update Tracker - [Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9776228] Update Tracker - [Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - v77:[addHasEvent, updateContainedRLE] [UpdateTracker:9776486] Update Tracker - [Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - v75:[addHasEvent]

Referrals

(hasEvent)

[Pathway:R-HSA-2262752] Cellular responses to stress

(updatedInstance)

[UpdateTracker:9774675] Update Tracker - [Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - v81:[addHasEvent]
[UpdateTracker:9776779] Update Tracker - [Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9776228] Update Tracker - [Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - v77:[addHasEvent, updateContainedRLE]
[UpdateTracker:9776486] Update Tracker - [Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - v75:[addHasEvent]

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