Reactome | AR binds AR antagonists

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AR binds AR antagonists Show undefined attributes

authored	[InstanceEdit:9706849] Jassal, Bijay, 2020-11-09
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9706849] Jassal, Bijay, 2020-11-09
dbId	9706837
displayName	AR binds AR antagonists
edited	[InstanceEdit:9706849] Jassal, Bijay, 2020-11-09 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
input	[DefinedSet:R-ALL-9706850] AR antagonists [cytosol] [Complex:R-HSA-9705922] HSP90:ATP:FKBP4:PTGES3:AR [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9707032] The preclinical development of bicalutamide: pharmacodynamics and mechanism of action [LiteratureReference:9707025] Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors [LiteratureReference:9707024] Clinical Development of Darolutamide: A Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer [LiteratureReference:9707016] ODM-201: a new-generation androgen receptor inhibitor in castration-resistant prostate cancer [LiteratureReference:9707045] ARN-509: a novel antiandrogen for prostate cancer treatment [LiteratureReference:9707030] Cortexolone 17?-propionate (Clascoterone) Is a Novel Androgen Receptor Antagonist that Inhibits Production of Lipids and Inflammatory Cytokines from Sebocytes In Vitro [LiteratureReference:9707036] Efficacy and Safety of Topical Clascoterone Cream, 1%, for Treatment in Patients With Facial Acne: Two Phase 3 Randomized Clinical Trials [LiteratureReference:9707061] Development of a second-generation antiandrogen for treatment of advanced prostate cancer
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	AR binds AR antagonists
orthologousEvent	[Reaction:R-PFA-9706837] AR binds AR antagonists - Plasmodium falciparum [Reaction:R-DME-9706837] AR binds AR antagonists - Drosophila melanogaster [Reaction:R-GGA-9706837] AR binds AR antagonists - Gallus gallus [Reaction:R-XTR-9706837] AR binds AR antagonists - Xenopus tropicalis [Reaction:R-DRE-9706837] AR binds AR antagonists - Danio rerio [Reaction:R-SSC-9706837] AR binds AR antagonists - Sus scrofa [Reaction:R-BTA-9706837] AR binds AR antagonists - Bos taurus [Reaction:R-CFA-9706837] AR binds AR antagonists - Canis familiaris [Reaction:R-RNO-9706837] AR binds AR antagonists - Rattus norvegicus [Reaction:R-MMU-9706837] AR binds AR antagonists - Mus musculus
output	[Complex:R-HSA-9706851] HSP90:ATP:FKBP4:PTGES3:AR:AR antagonists [cytosol]
reactionType	[DrugActionType:9725064] Antagonist
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9706837
summation	[Summation:9707034] The actions of androgens on the androgen receptors(AR) can p...

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[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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