Reactome | NR3C2 binds fludrocortisone

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NR3C2 binds fludrocortisone Show undefined attributes

authored	[InstanceEdit:9726503] Jassal, Bijay, 2021-04-07
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9726503] Jassal, Bijay, 2021-04-07
dbId	9726509
definition	Agonist
displayName	NR3C2 binds fludrocortisone
edited	[InstanceEdit:9726503] Jassal, Bijay, 2021-04-07 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
input	[ChemicalDrug:R-ALL-9726487] fludrocortisone [cytosol] [Complex:R-HSA-8948980] HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9726510] Impaired renal 11 beta-oxidation of 9 alpha-fluorocortisol: an explanation for its mineralocorticoid potency [LiteratureReference:9726512] Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers [LiteratureReference:9028631] Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	NR3C2 binds fludrocortisone
orthologousEvent	[Reaction:R-PFA-9726509] NR3C2 binds fludrocortisone - Plasmodium falciparum [Reaction:R-DME-9726509] NR3C2 binds fludrocortisone - Drosophila melanogaster [Reaction:R-GGA-9726509] NR3C2 binds fludrocortisone - Gallus gallus [Reaction:R-XTR-9726509] NR3C2 binds fludrocortisone - Xenopus tropicalis [Reaction:R-DRE-9726509] NR3C2 binds fludrocortisone - Danio rerio [Reaction:R-SSC-9726509] NR3C2 binds fludrocortisone - Sus scrofa [Reaction:R-BTA-9726509] NR3C2 binds fludrocortisone - Bos taurus [Reaction:R-CFA-9726509] NR3C2 binds fludrocortisone - Canis familiaris [Reaction:R-RNO-9726509] NR3C2 binds fludrocortisone - Rattus norvegicus [Reaction:R-MMU-9726509] NR3C2 binds fludrocortisone - Mus musculus
output	[Complex:R-HSA-9726499] NR3C2:fludrocortisone [cytosol]
reactionType	[DrugActionType:9725061] Agonist
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9726509
summation	[Summation:9726517] Fludrocortisone is a synthetic mineralocorticoid used in con...

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(hasEvent)

[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand