Reactome | PGR binds PGR antagonists

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PGR binds PGR antagonists Show undefined attributes

authored	[InstanceEdit:9726654] Jassal, Bijay, 2021-04-08
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9726654] Jassal, Bijay, 2021-04-08
dbId	9726621
displayName	PGR binds PGR antagonists
edited	[InstanceEdit:9726654] Jassal, Bijay, 2021-04-08 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
input	[Complex:R-HSA-9725890] HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] [DefinedSet:R-ALL-9726674] PGR antagonists [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9726597] Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators [LiteratureReference:9726612] 11-(pyridinylphenyl)steroids--a new class of mixed-profile progesterone agonists/antagonists
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PGR binds PGR antagonists
orthologousEvent	[Reaction:R-PFA-9726621] PGR binds PGR antagonists - Plasmodium falciparum [Reaction:R-DME-9726621] PGR binds PGR antagonists - Drosophila melanogaster [Reaction:R-GGA-9726621] PGR binds PGR antagonists - Gallus gallus [Reaction:R-XTR-9726621] PGR binds PGR antagonists - Xenopus tropicalis [Reaction:R-DRE-9726621] PGR binds PGR antagonists - Danio rerio [Reaction:R-SSC-9726621] PGR binds PGR antagonists - Sus scrofa [Reaction:R-BTA-9726621] PGR binds PGR antagonists - Bos taurus [Reaction:R-CFA-9726621] PGR binds PGR antagonists - Canis familiaris [Reaction:R-RNO-9726621] PGR binds PGR antagonists - Rattus norvegicus [Reaction:R-MMU-9726621] PGR binds PGR antagonists - Mus musculus
output	[Complex:R-HSA-9726623] PGR:PGR antagonists [cytosol]
reactionType	[DrugActionType:9725064] Antagonist
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9726621
summation	[Summation:9726812] The actions of progesterone, a critical regulator of normal ...

Referrals

(hasEvent)

[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand