Reactome | STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein

Schema > Reaction > Entries

STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein Show undefined attributes

authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3371552] Shamovsky, V, 2013-05-13
dbId	3371503
displayName	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
followingEvent	[Reaction:R-HSA-5618107] ATP binding to HSP90 triggers conformation change - Homo sapiens
input	[Complex:R-HSA-3371441] HSP40:HSP70:ADP:nascent protein [cytosol] [DefinedSet:R-HSA-3371429] HSP90:HSP90 [cytosol] [EntityWithAccessionedSequence:R-HSA-443857] STIP1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3371471] Heterogeneity and dynamics in the assembly of the heat shock protein 90 chaperone complexes [LiteratureReference:3371446] Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
orthologousEvent	[Reaction:R-PFA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Plasmodium falciparum [Reaction:R-SCE-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Saccharomyces cerevisiae [Reaction:R-SPO-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Schizosaccharomyces pombe [Reaction:R-DDI-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Dictyostelium discoideum [Reaction:R-DME-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Drosophila melanogaster [Reaction:R-GGA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Gallus gallus [Reaction:R-XTR-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Xenopus tropicalis [Reaction:R-DRE-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Danio rerio [Reaction:R-SSC-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Sus scrofa [Reaction:R-BTA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Bos taurus [Reaction:R-CFA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Canis familiaris [Reaction:R-RNO-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Rattus norvegicus [Reaction:R-MMU-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Mus musculus
output	[CandidateSet:R-HSA-3371594] HSP40s [cytosol] [Complex:R-HSA-3371444] HSP90:STIP1:HSP70:nascent protein [cytosol]
precedingEvent	[Reaction:R-HSA-3371422] ATP hydrolysis by HSP70 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16 [InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3371503
summation	[Summation:3371550] Stress-induced phosphoprotein 1 (STIP1, also known as HSP70-...

Referrals

(hasEvent)	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-HSA-5618107] ATP binding to HSP90 triggers conformation change

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