Reactome | NR3C1 binds NR3C1 agonists

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NR3C1 binds NR3C1 agonists Show undefined attributes

authored	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
dbId	9678925
definition	Agonist
displayName	NR3C1 binds NR3C1 agonists
edited	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[Complex:R-HSA-9605366] HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] [DefinedSet:R-ALL-9678859] NR3C1 agonists [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9028631] Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands [LiteratureReference:9605348] Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	NR3C1 binds NR3C1 agonists
orthologousEvent	[Reaction:R-PFA-9678925] NR3C1 binds NR3C1 agonists - Plasmodium falciparum [Reaction:R-DME-9678925] NR3C1 binds NR3C1 agonists - Drosophila melanogaster [Reaction:R-GGA-9678925] NR3C1 binds NR3C1 agonists - Gallus gallus [Reaction:R-XTR-9678925] NR3C1 binds NR3C1 agonists - Xenopus tropicalis [Reaction:R-DRE-9678925] NR3C1 binds NR3C1 agonists - Danio rerio [Reaction:R-SSC-9678925] NR3C1 binds NR3C1 agonists - Sus scrofa [Reaction:R-BTA-9678925] NR3C1 binds NR3C1 agonists - Bos taurus [Reaction:R-CFA-9678925] NR3C1 binds NR3C1 agonists - Canis familiaris [Reaction:R-RNO-9678925] NR3C1 binds NR3C1 agonists - Rattus norvegicus [Reaction:R-MMU-9678925] NR3C1 binds NR3C1 agonists - Mus musculus
output	[Complex:R-HSA-9678833] HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol]
reactionType	[DrugActionType:9725061] Agonist
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9678925
summation	[Summation:9681004] Corticosteroids bind to the glucocorticoid receptor NR3C1 (R...

Referrals

(hasEvent)

[Pathway:R-HSA-9679191] Potential therapeutics for SARS
[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand