Reactome | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10559118
displayName	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
eventOf	[Pathway:R-XTR-2262752] Cellular responses to stress - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:528568] cellular response to steroid hormone stimulus
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-XTR-3371590] HSP70 binds to HSP40:nascent protein - Xenopus tropicalis [Reaction:R-XTR-3371422] ATP hydrolysis by HSP70 - Xenopus tropicalis [Reaction:R-XTR-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Xenopus tropicalis [Reaction:R-XTR-5618107] ATP binding to HSP90 triggers conformation change - Xenopus tropicalis [Reaction:R-XTR-9705925] Androgens binds AR (in the HSP90 chaperone complex) - Xenopus tropicalis [Reaction:R-XTR-9705926] AR binds AR agonists - Xenopus tropicalis [Reaction:R-XTR-9706837] AR binds AR antagonists - Xenopus tropicalis [Reaction:R-XTR-9690534] NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) - Xenopus tropicalis [Reaction:R-XTR-9678925] NR3C1 binds NR3C1 agonists - Xenopus tropicalis [Reaction:R-XTR-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Xenopus tropicalis [Reaction:R-XTR-9725855] NR3C2 binds NR3C2 antagonists - Xenopus tropicalis [Reaction:R-XTR-9726509] NR3C2 binds fludrocortisone - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
isInDisease	false
isInferred	true
name	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSP90 chaperone cycle for SHRs
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3371497
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2262752] Cellular responses to stress
(inferredTo)	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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