Reactome | p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein

Schema > Reaction > Entries

p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein Show undefined attributes

authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5618086] Shamovsky, Veronica, 2014-08-18
dbId	5618098
displayName	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
followingEvent	[Reaction:R-HSA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Homo sapiens
input	[Complex:R-HSA-5618095] HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-265269] PTGES3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5324669] The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins [LiteratureReference:5324657] N-terminal domain of human Hsp90 triggers binding to the cochaperone p23
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
orthologousEvent	[Reaction:R-PFA-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Plasmodium falciparum [Reaction:R-DME-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Drosophila melanogaster [Reaction:R-GGA-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Gallus gallus [Reaction:R-SSC-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Sus scrofa [Reaction:R-BTA-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Bos taurus [Reaction:R-RNO-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Rattus norvegicus [Reaction:R-MMU-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Mus musculus
output	[Complex:R-HSA-5618079] HSP70:ATP [cytosol] [Complex:R-HSA-5618074] HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] [EntityWithAccessionedSequence:R-HSA-443857] STIP1 [cytosol]
precedingEvent	[Reaction:R-HSA-5618105] FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16 [InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5618098
summation	[Summation:5618114] Immunophilin p23 (also known as PTGES3) binds selectively to...

Referrals

(hasEvent)	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-HSA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein