Reactome | NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)

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NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) Show undefined attributes

authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5618086] Shamovsky, Veronica, 2014-08-18
dbId	5618099
displayName	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus - Homo sapiens
input	[Complex:R-HSA-8948980] HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] [DefinedSet:R-ALL-9027520] NR3C2 ligands [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8948327] Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation [LiteratureReference:8948280] Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)
orthologousEvent	[Reaction:R-PFA-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Plasmodium falciparum [Reaction:R-DME-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Drosophila melanogaster [Reaction:R-GGA-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Gallus gallus [Reaction:R-XTR-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Xenopus tropicalis [Reaction:R-DRE-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Danio rerio [Reaction:R-SSC-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Sus scrofa [Reaction:R-BTA-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Bos taurus [Reaction:R-CFA-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Canis familiaris [Reaction:R-RNO-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Rattus norvegicus [Reaction:R-MMU-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Mus musculus
output	[Complex:R-HSA-9725884] HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol]
precedingEvent	[Reaction:R-HSA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Homo sapiens [Reaction:R-HSA-5618110] p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16 [InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5618099
summation	[Summation:8948337] Steroid hormones receptors (SHRs) are intracellular transcri...
updateTrackers	[UpdateTracker:9776170] Update Tracker - [Reaction:5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - v77:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9776170] Update Tracker - [Reaction:5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - v77:[add_removeInput, add_removeOutput]
(precedingEvent)	[BlackBoxEvent:R-HSA-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus
(hasEvent)	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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