Reactome | FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein

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FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein Show undefined attributes

authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5618086] Shamovsky, Veronica, 2014-08-18
dbId	5618073
displayName	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
followingEvent	[Reaction:R-HSA-9690534] NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) - Homo sapiens [Reaction:R-HSA-9725885] P4 bind PGR (in the HSP90 chaperone complex) - Homo sapiens [Reaction:R-HSA-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5618108] FKBP4 [cytosol] [Complex:R-HSA-5618074] HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8944723] The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes [LiteratureReference:8944753] A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
orthologousEvent	[Reaction:R-PFA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Plasmodium falciparum [Reaction:R-DME-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Drosophila melanogaster [Reaction:R-GGA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Gallus gallus [Reaction:R-SSC-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Sus scrofa [Reaction:R-BTA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Bos taurus [Reaction:R-RNO-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Rattus norvegicus [Reaction:R-MMU-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-5618096] FKBP5 [cytosol] [Complex:R-HSA-5618101] HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol]
precedingEvent	[Reaction:R-HSA-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5618100] Positive regulation by 'SH [cytosol]'
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16 [InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5618073
summation	[Summation:8941423] Mass spectrometry analysis showed that FKBP51 (FKBP5) and FK...

Referrals

(precedingEvent)	[Reaction:R-HSA-9690534] NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) [Reaction:R-HSA-9725885] P4 bind PGR (in the HSP90 chaperone complex) [Reaction:R-HSA-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)
(hasEvent)	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand