Reactome | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107822
displayName	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
eventOf	[Pathway:R-SCE-2262752] Cellular responses to stress - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:528568] cellular response to steroid hormone stimulus
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SCE-3371590] HSP70 binds to HSP40:nascent protein - Saccharomyces cerevisiae [Reaction:R-SCE-3371422] ATP hydrolysis by HSP70 - Saccharomyces cerevisiae [Reaction:R-SCE-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Saccharomyces cerevisiae [Reaction:R-SCE-5618107] ATP binding to HSP90 triggers conformation change - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSP90 chaperone cycle for SHRs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-3371497
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-2262752] Cellular responses to stress
(inferredTo)	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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