Reactome | PGR binds PGR agonists

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PGR binds PGR agonists Show undefined attributes

authored	[InstanceEdit:9726654] Jassal, Bijay, 2021-04-08
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9726654] Jassal, Bijay, 2021-04-08
dbId	9726580
displayName	PGR binds PGR agonists
edited	[InstanceEdit:9726654] Jassal, Bijay, 2021-04-08 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
input	[Complex:R-HSA-9725890] HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] [DefinedSet:R-ALL-9726613] PGR agonists [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9726641] 5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists [LiteratureReference:9726620] Binding of progestagens to receptor proteins in MCF-7 cells [LiteratureReference:9726610] Selectivity and potency of the retroprogesterone dydrogesterone in vitro [LiteratureReference:9726584] 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents [LiteratureReference:9726607] Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PGR binds PGR agonists
orthologousEvent	[Reaction:R-PFA-9726580] PGR binds PGR agonists - Plasmodium falciparum [Reaction:R-DME-9726580] PGR binds PGR agonists - Drosophila melanogaster [Reaction:R-GGA-9726580] PGR binds PGR agonists - Gallus gallus [Reaction:R-XTR-9726580] PGR binds PGR agonists - Xenopus tropicalis [Reaction:R-DRE-9726580] PGR binds PGR agonists - Danio rerio [Reaction:R-SSC-9726580] PGR binds PGR agonists - Sus scrofa [Reaction:R-BTA-9726580] PGR binds PGR agonists - Bos taurus [Reaction:R-CFA-9726580] PGR binds PGR agonists - Canis familiaris [Reaction:R-RNO-9726580] PGR binds PGR agonists - Rattus norvegicus [Reaction:R-MMU-9726580] PGR binds PGR agonists - Mus musculus
output	[Complex:R-HSA-9726631] PGR:PGR agonists [cytosol]
reactionType	[DrugActionType:9725061] Agonist
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9726580
summation	[Summation:9726811] The actions of progesterone, a critical regulator of normal ...

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(hasEvent)

[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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