Reactome | AR binds AR agonists

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AR binds AR agonists Show undefined attributes

authored	[InstanceEdit:9705894] Jassal, Bijay, 2020-11-03
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9705894] Jassal, Bijay, 2020-11-03
dbId	9705926
displayName	AR binds AR agonists
edited	[InstanceEdit:9705894] Jassal, Bijay, 2020-11-03 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
input	[DefinedSet:R-ALL-9705896] AR agonists [cytosol] [Complex:R-HSA-9705922] HSP90:ATP:FKBP4:PTGES3:AR [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9706786] Relative binding affinities of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone [LiteratureReference:9706758] Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone [LiteratureReference:9706804] Molecular mechanisms of androgen action--a historical perspective [LiteratureReference:9706799] Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseases [LiteratureReference:9706745] Therapeutic effects of anabolic androgenic steroids on chronic diseases associated with muscle wasting [LiteratureReference:9706727] Wasting away: How to treat cachexia and muscle wasting in chronic disease? [LiteratureReference:9706736] A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids [LiteratureReference:9706754] Androgen Treatment in Adolescent Males With Hypogonadism [LiteratureReference:9706777] Hormonal profile of menopausal women receiving androgen replacement therapy: a meta-analysis [LiteratureReference:9706759] Acquired and hereditary forms of recurrent angioedema: Update of treatment [LiteratureReference:9706748] Androgens and endometrium: New insights and new targets [LiteratureReference:9706732] Androgens, oestrogens and endometrium: a fine balance between perfection and pathology [LiteratureReference:9706784] Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy [LiteratureReference:9706762] [Safety of long-term replacement hormonal therapy in patients with erectile dysfunction and androgen deficiency] [LiteratureReference:9706800] Androgen Deficiency and Phosphodiesterase Type 5 Expression Changes in Aging Male: Therapeutic Implications [LiteratureReference:9706792] Impact of androgen receptor expression in fluoxymesterone-treated estrogen receptor-positive metastatic breast cancer refractory to contemporary hormonal therapy [LiteratureReference:9706746] Androgen Receptor in Breast Cancer: From Bench to Bedside [LiteratureReference:9706734] Androgen Receptor Function and Androgen Receptor-Targeted Therapies in Breast Cancer: A Review
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	AR binds AR agonists
orthologousEvent	[Reaction:R-PFA-9705926] AR binds AR agonists - Plasmodium falciparum [Reaction:R-DME-9705926] AR binds AR agonists - Drosophila melanogaster [Reaction:R-GGA-9705926] AR binds AR agonists - Gallus gallus [Reaction:R-XTR-9705926] AR binds AR agonists - Xenopus tropicalis [Reaction:R-DRE-9705926] AR binds AR agonists - Danio rerio [Reaction:R-SSC-9705926] AR binds AR agonists - Sus scrofa [Reaction:R-BTA-9705926] AR binds AR agonists - Bos taurus [Reaction:R-CFA-9705926] AR binds AR agonists - Canis familiaris [Reaction:R-RNO-9705926] AR binds AR agonists - Rattus norvegicus [Reaction:R-MMU-9705926] AR binds AR agonists - Mus musculus
output	[Complex:R-HSA-9705910] HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol]
reactionType	[DrugActionType:9725061] Agonist
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9705926
summation	[Summation:9706750] Endogenous androgens such as testosterone and dihydrotestost...

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[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

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