Reactome | ATP hydrolysis by HSP70

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ATP hydrolysis by HSP70 Show undefined attributes

authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
catalystActivity	[CatalystActivity:3371447] ATP hydrolysis activity of HSP40:HSP70:ATP:nascent protein [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3371552] Shamovsky, V, 2013-05-13
dbId	3371422
displayName	ATP hydrolysis by HSP70
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
followingEvent	[Reaction:R-HSA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Homo sapiens
input	[Complex:R-HSA-3371563] HSP40:HSP70:ATP:nascent protein [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8938680] Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78 [LiteratureReference:8938653] Hsp70 chaperone dynamics and molecular mechanism
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ATP hydrolysis by HSP70
orthologousEvent	[Reaction:R-PFA-3371422] ATP hydrolysis by HSP70 - Plasmodium falciparum [Reaction:R-SCE-3371422] ATP hydrolysis by HSP70 - Saccharomyces cerevisiae [Reaction:R-SPO-3371422] ATP hydrolysis by HSP70 - Schizosaccharomyces pombe [Reaction:R-DDI-3371422] ATP hydrolysis by HSP70 - Dictyostelium discoideum [Reaction:R-CEL-3371422] ATP hydrolysis by HSP70 - Caenorhabditis elegans [Reaction:R-DME-3371422] ATP hydrolysis by HSP70 - Drosophila melanogaster [Reaction:R-GGA-3371422] ATP hydrolysis by HSP70 - Gallus gallus [Reaction:R-XTR-3371422] ATP hydrolysis by HSP70 - Xenopus tropicalis [Reaction:R-DRE-3371422] ATP hydrolysis by HSP70 - Danio rerio [Reaction:R-SSC-3371422] ATP hydrolysis by HSP70 - Sus scrofa [Reaction:R-BTA-3371422] ATP hydrolysis by HSP70 - Bos taurus [Reaction:R-CFA-3371422] ATP hydrolysis by HSP70 - Canis familiaris [Reaction:R-RNO-3371422] ATP hydrolysis by HSP70 - Rattus norvegicus [Reaction:R-MMU-3371422] ATP hydrolysis by HSP70 - Mus musculus
output	[Complex:R-HSA-3371441] HSP40:HSP70:ADP:nascent protein [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-3371590] HSP70 binds to HSP40:nascent protein - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-3371484] Positive regulation by 'HSP40s [cytosol]'
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16 [InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3371422
summation	[Summation:8938598] Heat shock protein 70 (HSP70) proteins bind and release clie...

Referrals

(hasEvent)	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-HSA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein

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