Reactome | Regulation of actin dynamics for phagocytic cup formation

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Regulation of actin dynamics for phagocytic cup formation Show undefined attributes

authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
dbId	2029482
displayName	Regulation of actin dynamics for phagocytic cup formation
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
eventOf	[Pathway:R-HSA-2029480] Fcgamma receptor (FCGR) dependent phagocytosis - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2029458] Recruitment of VAV1 to p-6Y-SYK - Homo sapiens [Reaction:R-HSA-2029453] Phosphorylation of VAV - Homo sapiens [Reaction:R-HSA-2029451] Activation of RAC1 by VAV - Homo sapiens [Reaction:R-HSA-2197697] Recruitment of CRKII:DOCK180:ELMO complex to FCGR - Homo sapiens [Reaction:R-HSA-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - Homo sapiens [Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens [Reaction:R-HSA-2029469] p-ERK phosphorylates WAVEs and ABI - Homo sapiens [Reaction:R-HSA-2130194] ABL phosphorylates WAVEs - Homo sapiens [BlackBoxEvent:R-HSA-2029445] An unknown GEF exchanges GTP for GDP on CDC42:GDP - Homo sapiens [Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 - Homo sapiens [Reaction:R-HSA-2197691] WIP binds WASP,N-WASP, activating them - Homo sapiens [Reaction:R-HSA-2197698] Src phosphorylate WASP,N-WASP - Homo sapiens [Reaction:R-HSA-442592] WASPs or WAVEs activate the ARP2/3 complex - Homo sapiens [Reaction:R-HSA-2029466] (WASPs, WAVE):G-actin:ARP2/3 binds F-actin - Homo sapiens [Reaction:R-HSA-2197690] Detachment of WASP/WAVE - Homo sapiens [BlackBoxEvent:R-HSA-2029473] Branching and elongation of mother and daughter filaments - Homo sapiens [Reaction:R-HSA-2029456] RAC1 and CDC42 activate PAK1 - Homo sapiens [Reaction:R-HSA-2029454] Autophosphorylation of PAK1 - Homo sapiens [Reaction:R-HSA-2029460] PAK1 phosphorylates LIMK1 - Homo sapiens [Reaction:R-HSA-419645] Dimerization of LIMK1 by Hsp90 - Homo sapiens [BlackBoxEvent:R-HSA-419644] Transphosphorylation of pLIMK1 - Homo sapiens [Reaction:R-HSA-399950] Phosphorylation of cofilin by LIMK-1 - Homo sapiens [Reaction:R-HSA-1861595] Extension of pseudopodia by myosin-X in a PI3K dependent manner - Homo sapiens [BlackBoxEvent:R-HSA-2029476] Role of myosins in phagosome formation - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:372997] Regulation of WASP/WAVE proteins: making a long story short [LiteratureReference:201914] Regulation of actin filament assembly by Arp2/3 complex and formins [LiteratureReference:2028951] Regulation of phagocytosis by Rho GTPases
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	Regulation of actin dynamics for phagocytic cup formation
orthologousEvent	[Pathway:R-MMU-2029482] Regulation of actin dynamics for phagocytic cup formation - Mus musculus [Pathway:R-RNO-2029482] Regulation of actin dynamics for phagocytic cup formation - Rattus norvegicus [Pathway:R-CFA-2029482] Regulation of actin dynamics for phagocytic cup formation - Canis familiaris [Pathway:R-BTA-2029482] Regulation of actin dynamics for phagocytic cup formation - Bos taurus [Pathway:R-SSC-2029482] Regulation of actin dynamics for phagocytic cup formation - Sus scrofa [Pathway:R-DRE-2029482] Regulation of actin dynamics for phagocytic cup formation - Danio rerio [Pathway:R-XTR-2029482] Regulation of actin dynamics for phagocytic cup formation - Xenopus tropicalis [Pathway:R-GGA-2029482] Regulation of actin dynamics for phagocytic cup formation - Gallus gallus [Pathway:R-DME-2029482] Regulation of actin dynamics for phagocytic cup formation - Drosophila melanogaster [Pathway:R-CEL-2029482] Regulation of actin dynamics for phagocytic cup formation - Caenorhabditis elegans [Pathway:R-DDI-2029482] Regulation of actin dynamics for phagocytic cup formation - Dictyostelium discoideum [Pathway:R-SPO-2029482] Regulation of actin dynamics for phagocytic cup formation - Schizosaccharomyces pombe [Pathway:R-SCE-2029482] Regulation of actin dynamics for phagocytic cup formation - Saccharomyces cerevisiae
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2029482
summation	[Summation:2028881] The actin cytoskeleton is fundamental for phagocytosis and m...

Referrals

(hasEvent)

[Pathway:R-HSA-2029480] Fcgamma receptor (FCGR) dependent phagocytosis

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