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Regulation of actin dynamics for phagocytic cup formation
Stable Identifier
R-HSA-2029482
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
General
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The actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and CDC42 exert their action through the members of WASP family proteins (WASP/N-WASP/WAVE) and ARP2/3 complex. Actin filaments move from the bottom toward the top of the phagocytic cup during pseudopod extension.
Literature References
PubMed ID
Title
Journal
Year
15452139
Regulation of WASP/WAVE proteins: making a long story short
Bompard, G
,
Caron, E
J Cell Biol
2004
17477841
Regulation of actin filament assembly by Arp2/3 complex and formins
Pollard, TD
Annu Rev Biophys Biomol Struct
2007
15981459
Regulation of phagocytosis by Rho GTPases
Chavrier, P
,
Niedergang, F
Curr Top Microbiol Immunol
2005
Participants
Events
Recruitment of VAV1 to p-6Y-SYK
(Homo sapiens)
Phosphorylation of VAV
(Homo sapiens)
Activation of RAC1 by VAV
(Homo sapiens)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR
(Homo sapiens)
Activation of RAC1 by CRKII:DOCK180:ELMO
(Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
(Homo sapiens)
p-ERK phosphorylates WAVEs and ABI
(Homo sapiens)
ABL phosphorylates WAVEs
(Homo sapiens)
An unknown GEF exchanges GTP for GDP on CDC42:GDP
(Homo sapiens)
Activation of WASP and N-WASP by CDC42
(Homo sapiens)
WIP binds WASP,N-WASP, activating them
(Homo sapiens)
Src phosphorylate WASP,N-WASP
(Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex
(Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin
(Homo sapiens)
Detachment of WASP/WAVE
(Homo sapiens)
Branching and elongation of mother and daughter filaments
(Homo sapiens)
RAC1 and CDC42 activate PAK1
(Homo sapiens)
Autophosphorylation of PAK1
(Homo sapiens)
PAK1 phosphorylates LIMK1
(Homo sapiens)
Dimerization of LIMK1 by Hsp90
(Homo sapiens)
Transphosphorylation of pLIMK1
(Homo sapiens)
Phosphorylation of cofilin by LIMK-1
(Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner
(Homo sapiens)
Role of myosins in phagosome formation
(Homo sapiens)
Participates
as an event of
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Orthologous Events
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
Regulation of actin dynamics for phagocytic cup formation (Dictyostelium discoideum)
Regulation of actin dynamics for phagocytic cup formation (Drosophila melanogaster)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Saccharomyces cerevisiae)
Regulation of actin dynamics for phagocytic cup formation (Schizosaccharomyces pombe)
Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
Regulation of actin dynamics for phagocytic cup formation (Xenopus tropicalis)
Authored
Garapati, P V (2012-01-04)
Reviewed
Rosales, C (2012-05-15)
Created
Garapati, P V (2012-01-04)
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