Reactome | Regulation of actin dynamics for phagocytic cup formation

Regulation of actin dynamics for phagocytic cup formation

Stable Identifier

R-HSA-2029482

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

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Regulation of actin dynamics for phagocytic cup formation

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The actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and CDC42 exert their action through the members of WASP family proteins (WASP/N-WASP/WAVE) and ARP2/3 complex. Actin filaments move from the bottom toward the top of the phagocytic cup during pseudopod extension.

Literature References

PubMed ID	Title	Journal	Year
17477841	Regulation of actin filament assembly by Arp2/3 complex and formins Pollard, TD	Annu Rev Biophys Biomol Struct	2007
15452139	Regulation of WASP/WAVE proteins: making a long story short Bompard, G, Caron, E	J Cell Biol	2004
15981459	Regulation of phagocytosis by Rho GTPases Niedergang, F, Chavrier, P	Curr Top Microbiol Immunol	2005