Reactome | Autophosphorylation of PAK1

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Autophosphorylation of PAK1 Show undefined attributes

authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
catalystActivity	[CatalystActivity:445074] protein serine/threonine kinase activity of PAK1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643360] protein serine/threonine kinase activity of PAK1 [cytosol] The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2029450] Garapati, P V, 2012-01-04
dbId	2029454
displayName	Autophosphorylation of PAK1
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:8981921] Orlic-Milacic, Marija, 2017-03-15
eventOf	[Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens
followingEvent	[Reaction:R-HSA-5668947] PAK1 phosphorylates myosin phosphatase - Homo sapiens [Reaction:R-HSA-5669240] FLNA binds PAK1 - Homo sapiens [Reaction:R-HSA-5668984] PAK1 or PAK2 phosphorylates MYLK - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2029159] RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 [LiteratureReference:399908] The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Autophosphorylation of PAK1
orthologousEvent	[Reaction:R-MMU-2029454] Autophosphorylation of PAK1 - Mus musculus [Reaction:R-SCE-2029454] Autophosphorylation of PAK1 - Saccharomyces cerevisiae [Reaction:R-SPO-2029454] Autophosphorylation of PAK1 - Schizosaccharomyces pombe [Reaction:R-DDI-2029454] Autophosphorylation of PAK1 - Dictyostelium discoideum [Reaction:R-CEL-2029454] Autophosphorylation of PAK1 - Caenorhabditis elegans [Reaction:R-DME-2029454] Autophosphorylation of PAK1 - Drosophila melanogaster [Reaction:R-GGA-2029454] Autophosphorylation of PAK1 - Gallus gallus [Reaction:R-XTR-2029454] Autophosphorylation of PAK1 - Xenopus tropicalis [Reaction:R-SSC-2029454] Autophosphorylation of PAK1 - Sus scrofa [Reaction:R-BTA-2029454] Autophosphorylation of PAK1 - Bos taurus [Reaction:R-CFA-2029454] Autophosphorylation of PAK1 - Canis familiaris [Reaction:R-RNO-2029454] Autophosphorylation of PAK1 - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [EntityWithAccessionedSequence:R-HSA-399819] p-S144,T423-PAK1 [cytosol]
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2029454
summation	[Summation:2028800] PAK1 needs autophosphorylation for complete activation. PAK1...
updateTrackers	[UpdateTracker:9780954] Update Tracker - [Reaction:2029454] Autophosphorylation of PAK1 - v61:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9780954] Update Tracker - [Reaction:2029454] Autophosphorylation of PAK1 - v61:[add_removeOutput]
(precedingEvent)	[Reaction:R-HSA-5669240] FLNA binds PAK1 [Reaction:R-HSA-5668984] PAK1 or PAK2 phosphorylates MYLK [Reaction:R-HSA-5668947] PAK1 phosphorylates myosin phosphatase
(hasEvent)	[Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation

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