Reactome | Phosphorylation of cofilin by LIMK-1

Schema > Reaction > Entries

authored	[InstanceEdit:399743] Garapati, P V, 2009-03-23 09:59:28
catalystActivity	[CatalystActivity:419883] protein serine/threonine kinase activity of Active LIMK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:399945] Garapati, P V, 2009-03-23 10:27:02
dbId	399950
displayName	Phosphorylation of cofilin by LIMK-1
edited	[InstanceEdit:399760] Garapati, P V, 2009-03-23 10:00:07
eventOf	[Pathway:R-HSA-399954] Sema3A PAK dependent Axon repulsion - Homo sapiens [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens
inferredFrom	[Reaction:R-NUL-421139] Limk1 phosphorylates Cfl1, inactivating it - Homo sapiens
input	[Complex:R-HSA-419630] Active LIMK1 [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-350751] CFL1 [cytosol]
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of cofilin by LIMK-1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-399878] pCofilin: Active LIMK-1 [cytosol]
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-399950
summation	[Summation:416561] The EPHB2-FAK pathway partially promotes dendritic spine sta...

(hasEvent)	[Pathway:R-HSA-399954] Sema3A PAK dependent Axon repulsion [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation
(inferredTo)	[Reaction:R-NUL-421139] Limk1 phosphorylates Cfl1, inactivating it