Reactome | Dimerization of LIMK1 by Hsp90

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Dimerization of LIMK1 by Hsp90 Show undefined attributes

authored	[InstanceEdit:399743] Garapati, P V, 2009-03-23 09:59:28
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:419648] Garapati, P V, 2009-05-05 12:44:47
dbId	419645
displayName	Dimerization of LIMK1 by Hsp90
edited	[InstanceEdit:399760] Garapati, P V, 2009-03-23 10:00:07
eventOf	[Pathway:R-HSA-399954] Sema3A PAK dependent Axon repulsion - Homo sapiens [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens
input	[DefinedSet:R-HSA-419619] HSP90AA1,HSP90AB1 [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-399816] p-T508-LIMK1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:419278] Hsp90 increases LIM kinase activity by promoting its homo-dimerization [LiteratureReference:419284] Lim kinases, regulators of actin dynamics
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Dimerization of LIMK1 by Hsp90
orthologousEvent	[Reaction:R-MMU-419645] Dimerization of LIMK1 by Hsp90 - Mus musculus [Reaction:R-DDI-419645] Dimerization of LIMK1 by Hsp90 - Dictyostelium discoideum [Reaction:R-DME-419645] Dimerization of LIMK1 by Hsp90 - Drosophila melanogaster [Reaction:R-GGA-419645] Dimerization of LIMK1 by Hsp90 - Gallus gallus [Reaction:R-XTR-419645] Dimerization of LIMK1 by Hsp90 - Xenopus tropicalis [Reaction:R-DRE-419645] Dimerization of LIMK1 by Hsp90 - Danio rerio [Reaction:R-SSC-419645] Dimerization of LIMK1 by Hsp90 - Sus scrofa [Reaction:R-BTA-419645] Dimerization of LIMK1 by Hsp90 - Bos taurus [Reaction:R-CFA-419645] Dimerization of LIMK1 by Hsp90 - Canis familiaris [Reaction:R-RNO-419645] Dimerization of LIMK1 by Hsp90 - Rattus norvegicus
output	[Complex:R-HSA-419632] pLIMK dimer:HSP-90 [cytosol]
precedingEvent	[Reaction:R-HSA-399952] Phosphorylation of LIMK-1 by PAK - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-419645
summation	[Summation:419597] After phosphorylation on Thr 508, LIMK undergoes homodimeriz...
updateTrackers	[UpdateTracker:9791187] Update Tracker - [Reaction:419645] Dimerization of LIMK1 by Hsp90 - v32:[removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9791187] Update Tracker - [Reaction:419645] Dimerization of LIMK1 by Hsp90 - v32:[removeInput]
(hasEvent)	[Pathway:R-HSA-399954] Sema3A PAK dependent Axon repulsion [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation