Reactome | RAC1 and CDC42 activate PAK1

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RAC1 and CDC42 activate PAK1 Show undefined attributes

authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2029450] Garapati, P V, 2012-01-04
dbId	2029456
displayName	RAC1 and CDC42 activate PAK1
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:8981921] Orlic-Milacic, Marija, 2017-03-15
eventOf	[Pathway:R-HSA-5627123] RHO GTPases activate PAKs - Homo sapiens [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens
followingEvent	[Reaction:R-HSA-5627775] Autophosphorylation of PAK1,2,3 - Homo sapiens
input	[DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [Complex:R-HSA-445002] PAK1 dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028946] Rapid association of cytoskeletal remodeling proteins with the developing phagosomes of human neutrophils [LiteratureReference:2028976] Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils [LiteratureReference:442644] Structural requirements for PAK activation by Rac GTPases
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RAC1 and CDC42 activate PAK1
orthologousEvent	[Reaction:R-MMU-2029456] RAC1 and CDC42 activate PAK1 - Mus musculus [Reaction:R-SCE-2029456] RAC1 and CDC42 activate PAK1 - Saccharomyces cerevisiae [Reaction:R-SPO-2029456] RAC1 and CDC42 activate PAK1 - Schizosaccharomyces pombe [Reaction:R-DDI-2029456] RAC1 and CDC42 activate PAK1 - Dictyostelium discoideum [Reaction:R-CEL-2029456] RAC1 and CDC42 activate PAK1 - Caenorhabditis elegans [Reaction:R-DME-2029456] RAC1 and CDC42 activate PAK1 - Drosophila melanogaster [Reaction:R-GGA-2029456] RAC1 and CDC42 activate PAK1 - Gallus gallus [Reaction:R-XTR-2029456] RAC1 and CDC42 activate PAK1 - Xenopus tropicalis [Reaction:R-SSC-2029456] RAC1 and CDC42 activate PAK1 - Sus scrofa [Reaction:R-BTA-2029456] RAC1 and CDC42 activate PAK1 - Bos taurus [Reaction:R-CFA-2029456] RAC1 and CDC42 activate PAK1 - Canis familiaris [Reaction:R-RNO-2029456] RAC1 and CDC42 activate PAK1 - Rattus norvegicus
output	[EntityWithAccessionedSequence:R-HSA-162629] PAK1 [cytosol] [Complex:R-HSA-2029159] RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-2029445] An unknown GEF exchanges GTP for GDP on CDC42:GDP - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8981922] Negative regulation by 'NF2 [plasma membrane]'
regulationReference	[RegulationReference:9642998] Negative regulation by 'NF2 [plasma membrane]' Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2029456
summation	[Summation:2028834] PAK1, a downstream effector of CDC42 and RAC1, is found loca...
updateTrackers	[UpdateTracker:9781091] Update Tracker - [Reaction:2029456] RAC1 and CDC42 activate PAK1 - v61:[addOutput, addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9781091] Update Tracker - [Reaction:2029456] RAC1 and CDC42 activate PAK1 - v61:[addOutput, addRegulator]
(hasEvent)	[Pathway:R-HSA-5627123] RHO GTPases activate PAKs [Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation
(precedingEvent)	[Reaction:R-HSA-5627775] Autophosphorylation of PAK1,2,3

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