Reactome | Regulation of actin dynamics for phagocytic cup formation

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Regulation of actin dynamics for phagocytic cup formation Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330279
displayName	Regulation of actin dynamics for phagocytic cup formation
eventOf	[Pathway:R-CFA-2029480] Fcgamma receptor (FCGR) dependent phagocytosis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-2029458] Recruitment of VAV1 to p-6Y-SYK - Canis familiaris [Reaction:R-CFA-2029453] Phosphorylation of VAV - Canis familiaris [Reaction:R-CFA-2029451] Activation of RAC1 by VAV - Canis familiaris [Reaction:R-CFA-2197697] Recruitment of CRKII:DOCK180:ELMO complex to FCGR - Canis familiaris [Reaction:R-CFA-2029467] Activation of RAC1 by CRKII:DOCK180:ELMO - Canis familiaris [Reaction:R-CFA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Canis familiaris [Reaction:R-CFA-2029469] p-ERK phosphorylates WAVEs and ABI - Canis familiaris [Reaction:R-CFA-2130194] ABL phosphorylates WAVEs - Canis familiaris [Reaction:R-CFA-2197691] WIP binds WASP,N-WASP, activating them - Canis familiaris [Reaction:R-CFA-2197698] Src phosphorylate WASP,N-WASP - Canis familiaris [Reaction:R-CFA-2029466] (WASPs, WAVE):G-actin:ARP2/3 binds F-actin - Canis familiaris [Reaction:R-CFA-2197690] Detachment of WASP/WAVE - Canis familiaris [BlackBoxEvent:R-CFA-2029473] Branching and elongation of mother and daughter filaments - Canis familiaris [Reaction:R-CFA-2029456] RAC1 and CDC42 activate PAK1 - Canis familiaris [Reaction:R-CFA-2029454] Autophosphorylation of PAK1 - Canis familiaris [Reaction:R-CFA-2029460] PAK1 phosphorylates LIMK1 - Canis familiaris [Reaction:R-CFA-419645] Dimerization of LIMK1 by Hsp90 - Canis familiaris [BlackBoxEvent:R-CFA-419644] Transphosphorylation of pLIMK1 - Canis familiaris [Reaction:R-CFA-1861595] Extension of pseudopodia by myosin-X in a PI3K dependent manner - Canis familiaris
inferredFrom	[Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of actin dynamics for phagocytic cup formation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-2029482
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2029480] Fcgamma receptor (FCGR) dependent phagocytosis
(inferredTo)	[Pathway:R-HSA-2029482] Regulation of actin dynamics for phagocytic cup formation

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