Reactome | STAT3 is phosphorylated downstream of active ALK

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STAT3 is phosphorylated downstream of active ALK Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9701523] Rothfels, Karen, 2020-09-26
dbId	9701524
diseaseReaction	[Reaction:R-HSA-9712079] ALK mutants bind STAT3 - Homo sapiens
displayName	STAT3 is phosphorylated downstream of active ALK
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent	[Reaction:R-HSA-9701525] p-Y705,S727-STAT3 dimerizes - Homo sapiens
input	[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-539044] STAT3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death [LiteratureReference:9701412] Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma [LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma [LiteratureReference:9701343] NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors [LiteratureReference:9701357] Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target [LiteratureReference:9843053] Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells [LiteratureReference:9843020] Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease [LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma [LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma [LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma [LiteratureReference:9701292] Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3 [LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells [LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	STAT3 is phosphorylated downstream of active ALK
orthologousEvent	[BlackBoxEvent:R-GGA-9701524] STAT3 is phosphorylated downstream of active ALK - Gallus gallus [BlackBoxEvent:R-XTR-9701524] STAT3 is phosphorylated downstream of active ALK - Xenopus tropicalis [BlackBoxEvent:R-SSC-9701524] STAT3 is phosphorylated downstream of active ALK - Sus scrofa [BlackBoxEvent:R-BTA-9701524] STAT3 is phosphorylated downstream of active ALK - Bos taurus [BlackBoxEvent:R-CFA-9701524] STAT3 is phosphorylated downstream of active ALK - Canis familiaris [BlackBoxEvent:R-RNO-9701524] STAT3 is phosphorylated downstream of active ALK - Rattus norvegicus [BlackBoxEvent:R-MMU-9701524] STAT3 is phosphorylated downstream of active ALK - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-539048] p-Y705,S727-STAT3 [cytosol]
precedingEvent	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9701524
summation	[Summation:9701516] STAT3 is phosphorylated at tyrosine 705 downstream of active...
updateTrackers	[UpdateTracker:9853301] Update Tracker - [BlackBoxEvent:9701524] STAT3 is phosphorylated downstream of active ALK - v87:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853301] Update Tracker - [BlackBoxEvent:9701524] STAT3 is phosphorylated downstream of active ALK - v87:[addLiteratureReference, add_removeInput, modifyText]
(normalReaction)	[Reaction:R-HSA-9712079] ALK mutants bind STAT3
(hasEvent)	[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-HSA-9701525] p-Y705,S727-STAT3 dimerizes

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